Heather Hendrickson

Heather Hendrickson is a microbiologist and a Senior Lecturer in Molecular Bioscience in the School of Natural and Computational Science at Massey University, Auckland, New Zealand. Her research is focussed on the evolution of bacterial cell shape, and the discovery of bacteriophages that can attack antibiotic-resistant bacteria and the bee disease American foulbrood.

Heather Hendrickson
Born
Salt Lake City
Academic background
Alma materUniversity of Pittsburgh
Thesis
  • Chromosome Architecture and Evolution in Bacteria (2008)
Doctoral advisorProfessor Jeffrey G. Lawrence
Academic work
InstitutionsMassey University
Websitemicrobialevolution.massey.ac.nz

Life and career

Hendrickson was born in Salt Lake City, Utah, and moved to California as a young child; she describes herself as "obsessed with birds and bugs from a really young age."[1] Her family members were conservative Church of Jesus Christ of Latter-Day Saints (Mormons) who did not believe in evolution; in her household there were rules such as "no drinking alcohol, coffee or tea, no popular music and no one smokes. Girls had to wear skirts to church and we were trained as a kid to be a homemaker."[1] However, by the time she went to graduate school in Pittsburgh, she had become an atheist.[1]

Hendrickson graduated from the University of Utah in 2000 with a Bachelor of Science, then completed a PhD in Molecular, Cellular and Developmental Biology at the University of Pittsburgh in 2008. She spent three years as a postdoctoral researcher at the Biochemistry Department of the University of Oxford, as an HFSP Long-Term Fellow, researching variability of DNA replication in Escherichia coli.[2][3] Hendrickson moved to the Albany campus of Massey University as a lecturer in evolutionary genetics, rising to Senior Lecturer in Molecular Bioscience in 2015.[4][5] She is currently the vice president of the New Zealand Microbiological Society.[6]

Research

Hendrickson studies microbial evolution, specifically bacteriophages and genomics of bacteria. Her research has two main components: transitions in bacterial evolution, including the evolution of cell shape,[7] and the discovery of new bacteriophages, especially ones which could counter antibiotic-resistant bacteria.[8] She uses a combination of experimental evolution, cell biology, and bacterial genomics.[6]

Bacterial evolution

Analysis of the evolutionary tree of bacteria suggests the ancestral bacterium was rod-shaped. Hendrickson studies the way bacteria like Deinococcus, Staphylococcus, and Streptococcus bacteria evolved a spherical shape.[9] All three of these genera lack the gene for the protein MreB (the equivalent of actin in eukaryotes) which controls the width of rod-shaped bacteria. Normally deleting this gene kills the bacterium, but Hendrickson's lab has evolved a rod-like bacterial strain that can withstand the deletion of the MreB gene, enabling them to study how a spherical shape has evolved.[9]

To study the process of endosymbiosis, where one single-celled organism captures and incorporates another into its body, Hendrickson and her collaborators ran 10,000-generation experiments with mixtures of amoebae and their bacterial prey, to monitor possible collaborative partnerships that formed and sequence their genomes.[10]

Bacteriophages

Hendrickson's lab works on discovering and understanding the biology of bacteriophages that attack the bacteria Pseudomonas, Lactocococus, Mycobacterium, and Paenibacillus.[9] In collaboration with the American Foulbrood Management Agency, they are currently investigating phages that kill the bacterium Paenibacillus larvae, which causes American foulbrood (AFB) disease in honey bees.[9] In New Zealand, antibiotics may not be used to control AFB because they leave residues in the honey, so hives are usually destroyed instead. The Hendrickson lab screens soil samples collected by beekeepers from beneath healthy hives, looking for bacteriophages that could be used to prevent AFB infection.[11]

Hendrickson and her colleagues also work on discovering new bacteriophages that might be effective against antibiotic-resistant bacteria.[12][13] Six of her students discovered bacteriophages that could kill Mycobacterium smegmatis, a relative of the tuberculosis bacterium M. tuberculosis, which can infect the lungs of vulnerable people such as cystic fibrosis sufferers.[14]

Selected works

References
  1. "Twelve Questions: Heather Hendrickson". New Zealand Herald. 23 October 2014. Retrieved 16 March 2020.
  2. "Heather Hendrickson". Curious Minds He Hihiri i te Mahara. 30 November 2016. Retrieved 12 March 2020.
  3. "2008 Awards | Human Frontier Science Program". www.hfsp.org. Retrieved 13 March 2020.
  4. "Dr Heather Hendrickson – Senior Lecturer – Massey University". www.massey.ac.nz. Retrieved 12 March 2020.
  5. "Heather Hendrickson". LinkedIn. Retrieved 12 March 2020.
  6. "Executive – NZMS". NZMS. Retrieved 15 March 2020.
  7. Yulo, Paul Richard Jesena; Hendrickson, Heather Lyn (2019). "The evolution of spherical cell shape; progress and perspective". Biochemical Society Transactions. 47 (6): 1621–1634. doi:10.1042/BST20180634. PMC 6925525. PMID 31829405.
  8. "Spotlight on health crisis". North Harbour News. 15 August 2014. Retrieved 14 March 2020.
  9. Morton, Jamie (1 January 2018). "Science Made Simple: Dr Heather Hendrickson". New Zealand Herald. Retrieved 12 March 2020.
  10. Morton, Jamie (16 December 2018). "The Kiwi unravelling the mysteries of complex life". New Zealand Herald.
  11. Morton, Jamie (15 January 2018). "Virus vs disease: New bid to help our honeybees". New Zealand Herald. Retrieved 12 March 2020.
  12. "Dr. Heather Hendrickson". Sci21. 2016. Retrieved 13 March 2020.
  13. Arnold, Naomi (14 July 2017). "'We've reached peak antibiotics'". Newsroom. Retrieved 13 March 2020.
  14. Chisholm, Donna (1 January 2019). "The war against infection: Superbugs vs super drugs". North & South. Retrieved 13 March 2020.
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