Hsp17 thermometer

In molecular biology, the Hsp17 thermometer is an RNA element (RNA thermometer) found in the 5' UTR of Hsp17 mRNA.[1] Hsp17 is a cyanobacterial heat shock protein belonging to the Hsp20 family.[2]

Hsp17 thermometer
Predicted secondary structure and sequence conservation of PinT small RNA
Identifiers
Rfam	RF02358
Other data
Domain(s)	Bacteria
GO	GO:0009266
SO	SO:0005836
PDB structures	PDBe

At physiological temperature (28 degrees Celsius) the Hsp17 thermometer forms a hairpin structure, preventing translation of Hsp17. Under heat shock conditions the hairpin structure melts and translation takes place.[1]

See also

• RNA thermometer
• ROSE element
• FourU thermometer
• Hsp90 cis-regulatory element
• Cyanobacterial RNA thermometers

References

1. Kortmann J, Sczodrok S, Rinnenthal J, Schwalbe H, Narberhaus F (2011). "Translation on demand by a simple RNA-based thermosensor". Nucleic Acids Res. 39 (7): 2855–2868. doi:10.1093/nar/gkq1252. PMC 3074152. PMID 21131278.
2. Török Z, Goloubinoff P, Horváth I, Tsvetkova NM, Glatz A, Balogh G, et al. (2001). "Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding". Proc Natl Acad Sci U S A. 98 (6): 3098–3103. doi:10.1073/pnas.051619498. PMC 30613. PMID 11248038.