IHPK1

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.[5]

IP6K1
Identifiers
Aliases	IP6K1, IHPK1, PiUS, inositol hexakisphosphate kinase 1
External IDs	OMIM: 606991 MGI: 1351633 HomoloGene: 56602 GeneCards: IP6K1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,724,294 bp[1] End 49,786,542 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 108,002,501 bp[2] End 108,048,782 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • inositol hexakisphosphate 5-kinase activity • transferase activity • inositol hexakisphosphate 1-kinase activity • nucleotide binding • ATP binding • inositol hexakisphosphate 3-kinase activity • kinase activity • inositol-1,3,4,5,6-pentakisphosphate kinase activity • inositol 5-diphosphate pentakisphosphate 5-kinase activity • inositol diphosphate tetrakisphosphate kinase activity • inositol heptakisphosphate kinase activity • GO:0001948 protein binding • inositol hexakisphosphate kinase activity Cellular component • cytoplasm • cell nucleus • nucleoplasm • fibrillar center • cytosol Biological process • phosphatidylinositol phosphorylation • inositol phosphate metabolic process • phosphorylation • inositol phosphate biosynthetic process • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9807	27399
Ensembl	ENSG00000176095	ENSMUSG00000032594
UniProt	Q92551	Q6PD10
RefSeq (mRNA)	NM_153273 NM_001006115 NM_001242829	NM_013785
RefSeq (protein)	NP_001006115 NP_001229758 NP_695005	NP_038813
Location (UCSC)	Chr 3: 49.72 – 49.79 Mb	Chr 9: 108 – 108.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000176095 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032594 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IHPK1 inositol hexaphosphate kinase 1".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3". Somat. Cell Mol. Genet. 24 (1): 71–4. doi:10.1007/BF02677496. PMID 9776982. S2CID 22338269.
• Schell MJ, Letcher AJ, Brearley CA, et al. (1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Lett. 461 (3): 169–72. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691. S2CID 6834292.
• Saiardi A, Erdjument-Bromage H, Snowman AM, et al. (2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr. Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768. S2CID 15311443.
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
• Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kamimura J, Wakui K, Kadowaki H, et al. (2004). "The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus". J. Hum. Genet. 49 (7): 360–5. doi:10.1007/s10038-004-0158-z. PMID 15221640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

See also

• Inositol-hexakisphosphate kinase