IL17RD

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene. [5]

IL17RD
Identifiers
Aliases	IL17RD, HH18, IL-17RD, IL17RLM, SEF, interleukin 17 receptor D
External IDs	OMIM: 606807 MGI: 2159727 HomoloGene: 9717 GeneCards: IL17RD
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 57,089,982 bp[1] End 57,170,306 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 27,038,941 bp[2] End 27,107,286 bp[2]
Gene ontology Molecular function • interleukin-17 receptor activity Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • membrane • Golgi membrane • cell membrane • integral component of plasma membrane • nucleoplasm Biological process • MAPK cascade • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54756	171463
Ensembl	ENSG00000144730	ENSMUSG00000040717
UniProt	Q8NFM7	Q8JZL1
RefSeq (mRNA)	NM_017563 NM_001318864	NM_027265 NM_134437
RefSeq (protein)	NP_001305793 NP_060033	NP_602319
Location (UCSC)	Chr 3: 57.09 – 57.17 Mb	Chr 14: 27.04 – 27.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

References

1. GRCh38: Ensembl release 89: ENSG00000144730 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040717 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Interleukin 17 receptor D". Retrieved 2016-04-17.

Further reading

• Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003). "Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation". J. Biol. Chem. 278 (16): 14087–91. doi:10.1074/jbc.C200606200. PMID 12604616.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.