ING5

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.[5][6]

ING5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C6W
Identifiers
Aliases	ING5, p28inhibitor of growth family member 5
External IDs	OMIM: 608525 MGI: 1922816 HomoloGene: 90955 GeneCards: ING5
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,687,085 bp[1] End 241,729,478 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,803,965 bp[2] End 93,822,101 bp[2]
Gene ontology Molecular function • methylated histone binding • GO:0001948 protein binding • metal ion binding • chromatin binding Cellular component • MOZ/MORF histone acetyltransferase complex • cell nucleus • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • DNA replication • negative regulation of growth • regulation of transcription, DNA-templated • histone acetylation • histone H3 acetylation • transcription, DNA-templated • protein acetylation • negative regulation of cell proliferation • positive regulation of apoptotic process • regulation of signal transduction by p53 class mediator • chromatin organization • positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84289	66262
Ensembl	ENSG00000168395	ENSMUSG00000026283
UniProt	Q8WYH8	Q9D8Y8
RefSeq (mRNA)	NM_032329 NM_001330161 NM_001330162	NM_025454
RefSeq (protein)	NP_001317090 NP_001317091 NP_115705	NP_079730
Location (UCSC)	Chr 2: 241.69 – 241.73 Mb	Chr 1: 93.8 – 93.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[6]

Interactions

ING5 has been shown to interact with EP300[5] and P53.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000168395 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026283 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID 12750254.
6. "Entrez Gene: ING5 inhibitor of growth family, member 5".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.