INPP5B

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[5][6]

INPP5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTC, 3N9V, 4CML, 5A7J, 5A7I
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	OMIM: 147264 MGI: 103257 HomoloGene: 69021 GeneCards: INPP5B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,860,697 bp[1] End 37,947,057 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.89 cM Start 124,741,850 bp[2] End 124,801,511 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity • GO:0001948 protein binding • hydrolase activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity • inositol phosphate phosphatase activity Cellular component • integral component of membrane • cytosol • endosome • phagocytic vesicle membrane • Golgi apparatus • early endosome membrane • membrane • cell membrane • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment • cytoplasm Biological process • flagellated sperm motility • in utero embryonic development • inositol phosphate metabolic process • regulation of protein processing • phosphatidylinositol dephosphorylation • spermatogenesis • regulation of small GTPase mediated signal transduction • signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3633	16330
Ensembl	ENSG00000204084	ENSMUSG00000028894
UniProt	P32019	Q8K337
RefSeq (mRNA)	NM_001297434 NM_005540 NM_001350227 NM_001350228	NM_008385
RefSeq (protein)	NP_001284363 NP_005531 NP_001337156 NP_001337157 NP_001352749 NP_001352750 NP_001352751 NP_001352752 NP_001352753 NP_001352754	NP_032411
Location (UCSC)	Chr 1: 37.86 – 37.95 Mb	Chr 4: 124.74 – 124.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000204084 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028894 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. doi:10.1016/S0021-9258(18)54920-6. PMID 1718960.
6. "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading

• Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets". J. Biol. Chem. 264 (15): 8873–7. doi:10.1016/S0021-9258(18)81874-9. PMID 2542294.
• Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370–7. doi:10.1074/jbc.270.16.9370. PMID 7721860.
• Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34". Cytogenet. Cell Genet. 66 (3): 164–6. doi:10.1159/000133691. PMID 8125013.
• Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase". Eur. J. Biochem. 234 (1): 216–24. doi:10.1111/j.1432-1033.1995.216_c.x. PMID 8529643.
• Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens". Genomics. 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.