INTS1

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. [5]

INTS1
Identifiers
Aliases	INTS1, INT1, NET28, integrator complex subunit 1, NDCAGF
External IDs	OMIM: 611345 MGI: 1915760 HomoloGene: 53111 GeneCards: INTS1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 1,470,277 bp[1] End 1,504,389 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,751,282 bp[2] End 139,775,674 bp[2]
Orthologs
Species	Human	Mouse
Entrez	26173	68510
Ensembl	ENSG00000164880	ENSMUSG00000029547
UniProt	Q8N201	Q6P4S8
RefSeq (mRNA)	NM_001080453	NM_026748
RefSeq (protein)	NP_001073922	NP_081024
Location (UCSC)	Chr 7: 1.47 – 1.5 Mb	Chr 5: 139.75 – 139.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

References

1. GRCh38: Ensembl release 89: ENSG00000164880 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029547 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Integrator complex subunit 1". Retrieved 2016-06-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.