Intergenic lcrF RNA thermometer
RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.[1][2]
| LcrF intergenic thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of LcrF intergenic thermometer | |
| Identifiers | |
| Rfam | RF02704 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0045975 ,GO:0009266 |
| SO | SO:0005836 |
| PDB structures | PDBe |
References
- Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P (February 2012). "Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence". PLoS Pathogens. 8 (2): e1002518. doi:10.1371/journal.ppat.1002518. PMC 3280987. PMID 22359501.
- Schwiesow L, Lam H, Dersch P, Auerbuch V (December 2015). "Yersinia Type III Secretion System Master Regulator LcrF". Journal of Bacteriology. 198 (4): 604–614. doi:10.1128/JB.00686-15. PMC 4751813. PMID 26644429.
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