Iron-sulfur cluster biosynthesis protein family

In molecular biology, the iron-sulfur cluster biosynthesis protein family of includes proteins involved in biogenesis of Fe-S clusters (iron-sulfur cluster insertion protein, Fe/S biogenesis protein). This family includes IscA, HesB, YadR and YfhF-like proteins. The hesB gene is expressed only under nitrogen fixation conditions, within nitrogen fixing cyanobacteria.[1] IscA, an 11 kDa member of the hesB family of proteins, binds iron and [2Fe-2S] clusters, and participates in the biosynthesis of iron-sulfur proteins. IscA is able to bind at least 2 iron ions per dimer.[2] Other members of this family include various hypothetical proteins that also contain the NifU-like domain suggesting that they too are able to bind iron and are involved in Fe-S cluster biogenesis. The HesB family are found in species as divergent as Homo sapiens (Human) and Haemophilus influenzae suggesting that these proteins are involved in basic cellular functions.[3]

Fe-S_biosyn
e.coli isca crystal structure to 2.3 a
Identifiers
SymbolFe-S_biosyn
PfamPF01521
InterProIPR000361
PROSITEPDOC00887
SCOP21nwb / SCOPe / SUPFAM

References
  1. Huang TC, Lin RF, Chu MK, Chen HM (March 1999). "Organization and expression of nitrogen-fixation genes in the aerobic nitrogen-fixing unicellular cyanobacterium Synechococcus sp. strain RF-1". Microbiology. 145 (3): 743–53. doi:10.1099/13500872-145-3-743. PMID 10217509.
  2. Cupp-Vickery JR, Silberg JJ, Ta DT, Vickery LE (April 2004). "Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli". J. Mol. Biol. 338 (1): 127–37. doi:10.1016/j.jmb.2004.02.027. PMID 15050828.
  3. Hwang DM, Dempsey A, Tan KT, Liew CC (November 1996). "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution". J. Mol. Evol. 43 (5): 536–40. Bibcode:1996JMolE..43..536H. doi:10.1007/BF02337525. PMID 8875867. S2CID 21873104.
This article incorporates text from the public domain Pfam and InterPro: IPR000361
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