James Kirklin

James K. Kirklin (born 1947 in Rochester, Minnesota)[1] is an American cardiac surgeon who has made significant scientific and surgical contributions in the fields of heart transplantation and mechanical circulatory support devices to assist the pumping action of the heart.[2] He is Professor of Surgery, former Director of the Division of Cardiothoracic Surgery (2006-2016),[3] Director of the James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO) (2016–present),[4] former Co-Director of the University of Alabama at Birmingham (UAB) Comprehensive Cardiovascular Center[5] and holds the James Kirklin Chair of Cardiovascular Surgery at UAB.[6]

James K. Kirklin
Born1947
Rochester, Minnesota, USA
NationalityAmerican
EducationHarvard Medical School
OccupationCardiac Surgeon
Known for
RelativesFather John W. Kirklin
Medical career
ProfessionHeart Surgeon
InstitutionsUniversity of Alabama at Birmingham, USA
Research

Biography

Kirklin is the son of the late heart surgery pioneer John W. Kirklin.[1] He graduated from Ohio State University in 1969, where he was an All-American diver.[7][8] He received his MD from Harvard Medical School in 1973 as a member of the Alpha Omega Alpha academic honor society.[7][9] Subsequently, he completed general and cardiothoracic surgery residencies at Massachusetts General Hospital in 1978 where he was Chief Resident, and pursued additional training at Boston Children's Hospital in 1979 and UAB School of Medicine, where he completed his training in 1981. He was appointed Assistant Professor of Surgery at UAB in 1981, Director of Cardiac Transplantation in 1986, Professor of Surgery in 1987, and in 2006 was named Director of the Division of Cardiothoracic Surgery.[6] Kirklin's surgical expertise included surgery for congenital heart disease, heart transplantation, and mechanical circulatory support pumps. In 2012, Kirklin and his colleagues developed the first Children's Hospital pediatric cardiac surgical unit in the state of Alabama. In 2017, at the age of 70, he retired from clinical surgery to direct the Kirklin Institute for Research in surgical outcomes.[10][11]

Scientific work

Kirklin and his colleagues at UAB pioneered the development of multi-institutional collaborative outcomes research in pediatric and adult heart transplantation and mechanical circulatory support.[12][13] In 2007, he was the first surgeon to bridge an infant with failing single ventricular heart to successful heart transplantation, with a longer term pediatric heart assist device called the Berlin Heart ventricular assist device.[14] In 2011, he was the first surgeon in North America to implant the HVAD continuous flow ventricular assist device in a child.[15] This nine-year-old girl was supported for 60 days and she then underwent successful cardiac transplantation.[15] In 2014, Kirklin was the first surgeon in North America to implant the Eva Heart continuous flow ventricular assist device.[16][17] In 2015, Kirklin led the surgical team that implanted the Berlin Heart on the youngest baby (17 days old) to receive extended (greater than 1 month) mechanical circulatory support (136 days) before undergoing successful heart transplantation.[18][19]

Kirklin and his colleagues at UAB established the Cardiac Transplant Research Database in 1990, which generated the first multi-institutional collaborative research in heart transplantation, producing numerous seminal publications over a 20-year span.[20] In 1993, Kirklin and his UAB research group initiated the Pediatric Heart Transplant Study Group, which became the Pediatric Heart Transplant Society (PHTS), and continues to lead the field in multi-instuitional studies.[21] In 2013, Kirklin was honored as a Founding Father of the PHTS. Kirklin's research group developed an international database platform for mechanical circulatory support (IMACS) within the International Society for Heart and Lung Transplantation (ISHLT) in 2012, and created and direct a global database for the World Society for Pediatric and Congenital Heart Surgery (WSPCHS) since 2017.[22]

Kirklin was Principal Investigator of the $15 million NIH-funded national Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2006-2017. Kirklin is Past President of the International Society for Heart and Lung Transplantation (2009-2010) and President Elect (2022) of the World Society for Pediatric and Congenital Heart Surgery. In April 2016, UAB established the James and John Kirklin Institute for Research in Surgical Outcomes.[23]

Kirklin was first author of the textbook of Heart Transplantation in 2002,[24] co-authored the fourth edition of the textbook of heart surgery Cardiac Surgery in 2013,[25][26] and co-edited the book Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease, 2nd Edition in 2019.[27] He served as Editor of the Journal of Heart and Lung Transplantation from 2000–2009,[28] and he is principal editor of the ISHLT Monograph Series.[29] In 2014 Kirklin was the first recipient of the ISHLT Distinguished Educator Award.[2] He has authored over 500 scientific publications.[30] In 2019 Kirklin was selected to receive the International Society for Heart and Lung Transplantation Lifetime Achievement Award.[31]

References
  1. "John W. Kirklin Is Dead at 86; Innovator in Cardiac Surgery - New York Times". Nytimes.com. 30 April 2004. Retrieved 11 September 2014.
  2. "International Society for Heart & Lung Transplantation Reveals 2014 Award Winners". Prweb.com. Retrieved 2 October 2017.
  3. "UAB Cardiothoracic Surgery Annual Report 2015-16 UAB Medicine Cardiothoracic Surgery 2015/16 Annual". Joomag.com. Retrieved 2 October 2017.
  4. Smith, MIchelle (26 September 2019). "UAB - School of Medicine - Surgery - KIRSO Home". Uab.edu. Retrieved 26 September 2019.
  5. Smith, Michelle (26 September 2019). "UAB - School of Medicine - Comprehensive Cardiovascular Center - About". Uab.edu. Retrieved 26 September 2019.
  6. Green, Tricia. "UAB - School of Medicine - Surgery - Kirklin, James K., M.D." Uab.edu. Retrieved 2 October 2017.
  7. "James Kirklin - CTSNet". Ctsnet.org. Retrieved 11 September 2014.
  8. "OhioStateBuckeyes.com :: The Ohio State University Official Athletic Site". Ohiostatebuckeyes.com. Retrieved 2 October 2017.
  9. "Alpha Omega Alpha - About Alpha Omega Alpha". Alphaomegaalpha.org. Retrieved 2 October 2017.
  10. "History Birmingham, Alabama (AL) - Children's of Alabama". Childrensal.org. Retrieved 2 October 2017.
  11. "Children's of Alabama". Childrensal.org. Retrieved 2 October 2017.
  12. Smith, Michelle (26 September 2019). "UAB - Interagency Registry for Mechanically Assisted Circulatory Support - Investigators". Uab.edu. Retrieved 26 September 2019.
  13. "Dr. James Kirklin to assume late father's post at UAB - Birmingham Business Journal". Birmingham Business Journal. Retrieved 11 September 2014.
  14. Pearce, F. Bennett; Kirklin, James K; Holman, William L; Barrett, Cindy S; Romp, Robb L; Lau, Yung R (2009). "Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flow". The Journal of Thoracic and Cardiovascular Surgery. 137 (1): e40–2. doi:10.1016/j.jtcvs.2008.02.044. PMID 19154881.
  15. Kirklin, James K; Pearce, F. Bennett; Pamboukian, Salpy V; Alten, Jeffrey A; Borasino, Santiago; Carlo, Waldemer F; Holman, William L (2012). "Implantation of the Heart Ware HVAD in a Child After a Recent Thromboembolic Stroke". The Annals of Thoracic Surgery. 93 (3): 977–8. doi:10.1016/j.athoracsur.2011.08.060. PMID 22364990.
  16. Walsh, Lauren. "UAB patient becomes first outside Japan with new heart implant". Abc3340.com. Retrieved 2 October 2017.
  17. Smith, Michelle (26 September 2019). "Hayden Man is First Outside Japan to Receive New Heart Implant - UAB Medicine News - UAB Medicine". Uabmedicine.org. Retrieved 26 September 2019.
  18. "Auburn, LSU families brought together through tragedy - ESPN Video". Espn.com. Retrieved 2 October 2017.
  19. "Auburn heart transplant recipient meets donor family, families encourage community to donate life". Oanow.com. Retrieved 2 October 2017.
  20. Kerry Gorelick. "UAB - Department of Surgery - James K. Kirklin, MD, Director". Uab.edu. Retrieved 11 September 2014.
  21. "UAB - SOM - Pediatric Heart Transplant Study (PHTS) - Home". Uab.edu. Retrieved 11 September 2014.
  22. "World Society for Pediatric and Congenital Heart Surgery". World Society for Pediatric and Congenital Heart Surgery. 26 September 2019. Retrieved 26 September 2019.
  23. Alexander, Alan (16 June 2016). "UAB creates new surgical outcomes institute in honor of Kirklin family". www.bizjournals.com. Retrieved 8 February 2019.
  24. Deng, Mario C (2002). "Heart Transplantation. By James K. Kirklin, James B. Young, and David C. McGiffin. 883 pp., illustrated. New York, Churchill Livingstone, 2002. $229. ISBN 0-443-07655-3". New England Journal of Medicine. 347 (26): 2175–6. doi:10.1056/NEJM200212263472620.
  25. Nicholas t. Kouchoukos, MD; Eugene h. Blackstone, MD; Frank l. Hanley, MD; James k Kirklin, MD (2012-10-26). Kirklin/Barratt-Boyes Cardiac Surgery, Expert Consult - Online and Print (2 ... - Nicholas T. Kouchoukos, Eugene H. Blackstone, Frank L. Hanley, James K. Kirklin - Google Books. ISBN 978-1416063919. Retrieved 11 September 2014.
  26. "James Kirklin, MD, Cardiac Surgery Author – Elsevier AuthorsElsevier Authors". Elsevier Authors. Retrieved 11 September 2014.
  27. "Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease - 9780323566995 | US Elsevier Health Bookshop". www.us.elsevierhealth.com. Retrieved 2019-09-26.
  28. "ISHLT: The International Society for Heart & Lung Transplantation". Ishlt.org. Retrieved 2 October 2017.
  29. "ISHLT: The International Society for Heart & Lung Transplantation - Monograph Series". ishlt.org. Retrieved 2019-09-26.
  30. Search Results for author Kirklin JK on PubMed.
  31. "ISHLT: The International Society for Heart & Lung Transplantation - Lifetime Achievement". ishlt.org. Retrieved 2019-09-26.
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