Jennifer Stow

Jennifer Lea Stow is deputy director (research), NHMRC Principal Research Fellow and head of the Protein Trafficking and Inflammation laboratory at the Institute for Molecular Bioscience (IMB), The University of Queensland, Australia.[1] She was awarded her PhD from Monash University in Melbourne in 1982.[2] As a Fogarty International Fellow, she completed postdoctoral training at Yale University School of Medicine (US) in the Department of Cell Biology. She was then appointed to her first faculty position as an assistant professor at Harvard University in the Renal Unit, Departments of Medicine and Pathology at the Massachusetts General Hospital in Boston. At the end of 1994 she returned to Australia as a Wellcome Trust Senior International Medical Research fellow at The University of Queensland where her work has continued. Stow sits on national and international peer review and scientific committees and advisory boards. She has served as head of IMB's Division of Molecular Cell Biology, and in 2008 she was appointed as deputy director (research).[3]

Jennifer Lea Stow
NationalityAustralian
Alma materMonash University B.Sc.
Ph.D. (1982)
Known forProtein trafficking and inflammation
AwardsFogarty International Fellowship, Yale University (1982–1985)
Wellcome Trust Senior Research Fellowship in Medical Sciences (1994–1999)
NHMRC Principal Research Fellow
State Winner, Smart Women/Smart State Award, Queensland (2007)
Scientific career
FieldsCell biology
InstitutionsThe University of Queensland
Harvard University
Yale University
ThesisExperimental studies on glomerular cells and basement membrane in culture (1982)
Doctoral advisorEric Glasgow, Robert Atkins
InfluencesMarilyn Farquhar

Biography

Jenny Stow completed her tertiary education at Monash University Melbourne. Her undergraduate science degree was followed by an honours year (Hons 1st class) in the Department of Immunology and Pathology and a PhD (1979–1982) in the Department of Anatomy and Prince Henry's Hospital, under the supervision of Professors Eric Glasgow and Robert Atkins. Stow's PhD project involved characterizing cell populations in glomerulonephritis, and included the use of electron microscopy.[2]

She was then awarded a Fogarty International Fellowship for postdoctoral training in the Department of Cell Biology at Yale University School of Medicine, US, where she worked with one of the luminaries of cell biology and nephrology, Dr Marilyn Farquhar. Stow, Farquhar and colleagues published seminal studies on glomerular basement membranes and proteoglycans.

Upon leaving Yale, Stow took up her first faculty position as an assistant professor in the Renal Unit at Massachusetts General Hospital at Harvard University. Stow and colleagues published important findings on secretion in polarized epithelial cells and published the first evidence showing trimeric G proteins functioning in membrane trafficking.

At the end of 1994 Stow returned to Australia as a Wellcome Trust Senior Medical Research Fellow to set up a cell biology laboratory[3] at the University of Queensland in Brisbane. The Centre she joined later became of Australia's largest research institutes, UQ's Institute for Molecular Bioscience, where she has served as a group leader, professor and principal research fellow of the NHMRC.

Appointed head of IMB's Division of Molecular Cell Biology and then subsequently as deputy director (research) at IMB, Stow has performed roles in science, teaching and training and research policy. Her focus has been in cell biology, where her interest in protein trafficking and secretion is pursued using techniques such as microscopy and fluorescence imaging. Her current work in inflammation and cancer focuses on trafficking in epithelial cells and on cytokine secretion in macrophages.[4][5] She is known for discovering new pathways for secretion and recycling in cells and for defining new functions for the cell machinery, including large and small G proteins, myosins and SNAREs.

Career history
  • 2008-current, National Health and Medical Research Council (NHMRC) Principal Research Fellow, professorial research fellow, The University of Queensland
  • current, deputy director (research) and group leader, Institute for Molecular Bioscience, jointly appointed to School of Biomedical Science, The University of Queensland (renewed 2012)
  • 2006–2008, division head and professor, Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland
  • 2001–2006, NHMRC Principal Research Fellow (continuing), associate professor and group leader, Institute for Molecular Bioscience and Faculty of Biological and Chemical Sciences, The University of Queensland, Brisbane, Australia
  • 2000, principal research fellow (continuing), associate professor and group leader, Centre for Molecular and Cellular Biology (now the IMB) and Department of Biochemistry, The University of Queensland, Brisbane, Australia
  • 1994–1999, Wellcome Trust Senior Research Fellow (fixed term), Associate Professor and Group Leader, Centre for Molecular and Cellular Biology (now the IMB) and Department of Biochemistry, The University of Queensland, Brisbane, Australia
  • 1989–1995, assistant professor, Departments of Medicine and Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, US
  • 1985–1988, research scientist and Swebelius Cancer Research fellow, Department of Cell Biology, Yale University School of Medicine, Connecticut, US
  • 1982–1985, Fogarty International Research Postdoctoral fellow, Department of Cell Biology, Yale University School of Medicine, Connecticut, US. Mentor: Prof. Marilyn G. Farquhar

Career highlights
  • 1982 PhD awarded, Monash University, Melbourne Australia[2]
  • 1982 Fogarty International Fellowship for postdoctoral work at Yale University School of Medicine
  • 1985 Produced first antibody to basement membrane HSPG and localized glomerular filter HSPG
  • 1986 Swebeilius Cancer Research fellowship, US
  • 1987 Discovered mechanism for pH dependent sorting in epithelial cells[6]
  • 1988 Appointment at Harvard University/Massachusetts General Hospital as Assistant Professor[7]
  • 1990 Discovered new role for heterotrimeric G proteins in trafficking[8]
  • 1990 First independent NIH RO1 grant awarded
  • 1991 PI and Core Director, Renal Cell Biology NIH program
  • 1993 Established investigator of the American Heart Association
  • 1994 Wellcome Trust Senior Medical Research Fellowship[3]
  • 1994 Appointed as associate professor to The University of Queensland, Brisbane, Australia[1]
  • 1999 Discovered new recycling pathway for E-cadherin trafficking and regulation[9]
  • 2001 NHMRC Principal Research Fellowship (5-year career award)
  • 2001 Appointed as Associate Editor of American Journal of Physiology
  • 2005 Appointed as Professorial Research Fellow University of Queensland
  • 2005 Discovered new pathway for cytokine secretion in macrophages[10]
  • 2007 State Winner, Smart Women/Smart State Award, Queensland Australia
  • 2008 Chair of Grant Review Committee for Human Frontier Science Program
  • 2008 Appointed Deputy Director (Research) Institute for Molecular Bioscience
  • 2008 Appointed to Editorial Board of the journal Physiology
  • 2009 Davson Distinguished Lecturer for the American Physiological Society
  • 2009 Appointed to Medical Research Advisory Committee, Australian Cancer Research Foundation
  • 2010 Discovered role for PI3K in cell secretion and inflammation[11]
  • 2011 Walter Mackenzie Visiting Speaker, University of Alberta, Canada
  • 2014 Discovered role for PI3K and Rab8 in regulating inflammation[12][13]
  • 2019 Elected to EMBO[14]

Selected publications
  • Condon, N.D.; Wall, A.A.; Yeo, J.C.; Hamilton, N.A.; Stow, J.L. (2017), Botelho, Roberto (ed.), "Image-Based Analysis of Phagocytosis: Measuring Engulfment and Internalization", Phagocytosis and Phagosomes, Springer New York, 1519, pp. 201–214, doi:10.1007/978-1-4939-6581-6_13, ISBN 9781493965793, PMID 27815881
  • Yeo, J.C.; Wall, A.A.; Luo, L.; Condon, N.D.; Stow, J.L. (2016). "Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages: APPL Regulation of TLR4 Signaling". Traffic. 17 (9): 1014–1026. doi:10.1111/tra.12415. PMID 27219021.
  • Tuong, Z.K.; Lau, P.; Du, X.; Condon, N.D.; Goode, J.M.; Oh, T.G.; Yeo, J.C.; Muscat, G.E.O.; Stow, J.L. (2016). Bozza, P.T. (ed.). "RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages". PLOS ONE. 11 (1): e0147179. doi:10.1371/journal.pone.0147179. ISSN 1932-6203. PMC 4727927. PMID 26812621.
  • Luo, L.; Xue, J.; Kwan, A.; Gamsjaeger, R.; Wielens, J.; von Kleist, L.; Cubeddu, L.; Guo, Z.; Stow, J.L. (2016). "The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements". Journal of Biological Chemistry. 291 (18): 9411–9424. doi:10.1074/jbc.M115.703108. ISSN 0021-9258. PMC 4850282. PMID 26893375.
  • Chen, K.W.; Bezbradica, J.S.; Groß, C.J.; Wall, A.A.; Sweet, M.J.; Stow, J.L.; Schroder, K. (2016). "The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists". European Journal of Immunology. 46 (4): 1004–1010. doi:10.1002/eji.201545943. PMID 27062120.

References
  1. "Professor Jennifer Stow". imb.uq.edu.au. 2019-07-25. Retrieved 2019-07-25.
  2. Stow, Jennifer Lea; Thesis, Monash University (1982). Experimental studies on glomerular cells and basement membrane in culture. [Melbourne].
  3. Jennifer Stow Research Lab (Members) UQ, IMB
  4. "ORCID". orcid.org. Retrieved 2019-07-25.
  5. "Jennifer L. Stow - Google Scholar Citations". scholar.google.com.au. Retrieved 2019-07-25.
  6. Caplan MJ, Stow JL, Newman AP, et al. (1987). "Dependence on pH of polarized sorting of secreted proteins". Nature. 329 (6140): 632–5. doi:10.1038/329632a0. PMID 2821405.
  7. Jennifer Stow University of Queensland. Retrieved 2019-07-27
  8. Ercolani L, Stow JL, Boyle JF, et al. (June 1990). "Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells". Proceedings of the National Academy of Sciences of the United States of America. 87 (12): 4635–9. doi:10.1073/pnas.87.12.4635. PMC 54171. PMID 1693774.
  9. Le TL, Yap AS, Stow JL (July 1999). "Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics". The Journal of Cell Biology. 146 (1): 219–32. doi:10.1083/jcb.146.999.219. PMC 2199726. PMID 10402472.
  10. Murray RZ, Kay JG, Sangermani DG, Stow JL (December 2005). "A role for the phagosome in cytokine secretion". Science. 310 (5753): 1492–5. doi:10.1126/science.1120225. PMID 16282525.
  11. Low PC, Misaki R, Schroder K, et al. (September 2010). "Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion". The Journal of Cell Biology. 190 (6): 1053–65. doi:10.1083/jcb.201001028. PMC 3101599. PMID 20837769.
  12. Luo L, Wall AA, Yeo JC, et al. (2014). "Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling" (PDF). Nature Communications. 5: 4407. doi:10.1038/ncomms5407. PMID 25022365.
  13. Low PC, Manzanero S, Mohannak N, et al. (2014). "PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model". Nature Communications. 5: 3450. doi:10.1038/ncomms4450. PMID 24625684.
  14. Queensl, The University of; Lucia, Australia Brisbane St; Gatton, QLD 4072 +61 7 3365 1111 Other Campuses: UQ; Maps, UQ Herston; Queensl, Directions © 2019 The University of. "UQ researcher elected to eminent European scientific organisation". UQ News. Retrieved 2019-07-25.
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