Jill James

Sandra Jill James is an American biochemist and autism researcher who studies metabolic autism biomarkers. She works at Arkansas Children's Hospital Research Institute, where she is the director of the Metabolic Genomics Laboratory, as well as the University of Arkansas for Medical Sciences's department of pediatrics, where she has worked since 2002.[1][2] She is also a member of the Autism Speaks Treatment Advisory Board,[3] and is also a scientific advisor to the autism foundation N of One.[4] Her current research focuses on the role of epigenetics in causing autism, as well as the effectiveness of supplements as a treatment for autism and the potential existence of abnormal metabolism in autistic children. This research is funded by a 5-year grant from the National Institutes of Health entitled "Metabolic biomarkers of autism: predictive potential and genetic susceptibility," as well as by a grant from Autism Speaks.[5]

Sandra Jill James
Alma materMills College, University of California, Los Angeles
Known forDiscovery of metabolic abnormalities in autistic children
Scientific career
FieldsAutism, Metabolism
InstitutionsArkansas Children's Hospital
ThesisAlterations in macrophage and T cell immune activity in the zinc deficient mouse (1986)

Education

James obtained her bachelor's degree in biology from Mills College in 1962, followed by an M.S. and Ph.D. from the University of California, Los Angeles in 1982 and 1986, respectively.[6]

Research

James, while at the NCTR, conducted research on the role of DNA methylation and cancer susceptibility, and also studied metabolic differences in children with Down syndrome.[7] Her studies of children with Down syndrome showed that they have abnormal methionine metabolic pathways.[8]

Leukemia

James has also researched children suffering from leukemia in Fallon, Nevada. She originally received a grant from the EPA to conduct this research in 2004,[9] and presented preliminary results the following year, in which she reported that the Fallon children have a metabolic predisposition to develop leukemia, though the cancer itself is caused by environmental contaminants.[10] She never published her final results, because she only had 20 blood samples--"not enough to reach a conclusive result."[11]

Autism

James is best known for her autism-related research. Regarding autism, James' view is that the transsulfuration pathway is disrupted in autistic children, resulting in these children being deficient in glutathione, as well as vitamins such as vitamin B6 and vitamin B12,[12] and that maternal glutathione deficiency may also be a risk factor for autism.[13] She has also found that administering these compounds as supplements, as well as methylcobalamin and folinic acid, to autistic children can significantly restore their levels of glutathione and cysteine and may therefore be useful in the treatment of autism.[14][15] In addition, she has produced evidence that autistic children also suffer from impaired methylation capacity[16] and that, according to a study she presented at the 2005 Experimental Biology conference, they have a unique biological "fingerprint" in their blood which neurotypical children lack.[17] With regard to this particular study, James said that "One interpretation of this finding is that children with autism would be less able to detoxify and eliminate these heavy metals."[18][19] According to the official blog of Autism Speaks, James found that autistic children exhibit abnormal folate metabolism that is detectable by higher levels of plasma homocysteine, adenosine, and S-adenosyl-L-homocysteine in the mothers of these children.[20][21] Her glutathione-related research has been cited by anti-vaccinationists such as Robert F. Kennedy, Jr., Dan Olmsted, and David Kirby as evidence that autistic children lack sufficient glutathione to remove mercury from their bodies and are therefore more susceptible to the toxicity of mercury in vaccines.[22][23] However, James herself has cautioned against such conclusions, saying they are an overstatement of what her research actually shows; with specific regard to Kirby's claims, she said, "I'm afraid Mr. Kirby is overstating our conclusions -- which did not mention mercury. We simply showed for the first time that children with autism have lower levels of the major intracellular antioxidant, glutathione, which incidentally happens to be the major mechanism for mercury elimination from the body."[24] On March 27, 2012, the Jane Botsford Johnson Foundation awarded a $1.2 million research grant to Arkansas Children's Hospital to fund research into autism biomarkers; this research will be led by James. At the time the grant was being awarded, Johnson herself said that "Jill James' work at ACHRI holds great promise for the future of autism therapy and prevention."[25]

In vitro studies

Another field of her research that has attracted attention is a number of in vitro studies she has conducted regarding the toxicity of thimerosal to neuronal and glial cells; which, she has concluded, is mediated by glutathione.[26] She has said that these results "suggest that these children may have an increased vulnerability to pro-oxidant environmental exposures and a lower threshold for oxidative neurotoxicity and immunotoxicity."[27]

References
  1. S Jill James, PhD
  2. Research
  3. "Treatment Advisory Board Biographies". Autism Speaks. Retrieved 19 October 2013.
  4. "S. Jill James". Nofone.org.
  5. Jill James Biography
  6. "S. Jill James". University of Arkansas for Medical Sciences. Archived from the original on 27 March 2015. Retrieved 19 October 2013.
  7. "Study Offers More Evidence of Role Folic Acid Plays Against Down Syndrome". Los Angeles Times. Associated Press. 29 September 1999. Retrieved 10 March 2014.
  8. Jepson, Bryan (2007). Changing the Course of Autism: A Scientific Approach for Parents and Physicians. Sentient Publications. p. 108. ISBN 9781591810612.
  9. "EPA gives grant to leukemia cluster study". USA Today. Associated Press. 18 June 2004. Retrieved 20 April 2014.
  10. "Research: Genetics, contaminants may have role in Fallon cluster". UT-San Diego. Associated Press. 10 October 2009. Retrieved 5 April 2014.
  11. Crane-Murdoch, Sierra (5 April 2014). "Looking for Answers in a Town Known for Leukemia". The Atlantic. Retrieved 4 May 2014.
  12. Autism Coach Product Catalog and Information Website
  13. Dana, Joe (28 May 2009). "Potential breakthroughs in Autism research". AZCentral. Retrieved 3 March 2014.
  14. James, S. J.; Melnyk, S.; Fuchs, G.; Reid, T.; Jernigan, S.; Pavliv, O.; Hubanks, A.; Gaylor, D. W. (2008). "Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism". American Journal of Clinical Nutrition. 89 (1): 425–430. doi:10.3945/ajcn.2008.26615. PMC 2647708. PMID 19056591.
  15. Kirchhoff, Sallie (2008). Hope for the Autism Spectrum. Jessica Kingsley Publishers. p. 185. ISBN 9781846428579.
  16. James, S. Jill (December 2004). "Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism". Am. J. Clin. Nutr. 80 (6): 1611–1617. doi:10.1093/ajcn/80.6.1611. PMID 15585776.
  17. Raloff, Janet (2005). "Blood hints at autism's source". Science News. Retrieved 19 October 2013.
  18. Hotz, Robert Lee (3 April 2005). "Study Links Free Radicals to the Spectrum of Autism". Los Angeles Times. Retrieved 19 October 2013.
  19. "Autism Linked with Low Levels of Antioxidants". New York-Presbyterian Hospital. 13 April 2005. Retrieved 6 November 2013.
  20. More about Prenatal Folic Acid and Autism. Autism Speaks official blog. Retrieved on December 14, 2013.
  21. James, S. J.; Melnyk, S.; Jernigan, S.; Pavliv, O.; Trusty, T.; Lehman, S.; Seidel, L.; Gaylor, D. W.; Cleves, M. A. (2010). "A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism". American Journal of Medical Genetics Part B. 153B (6): 1209–1220. doi:10.1002/ajmg.b.31094. PMC 2943349. PMID 20468076.
  22. Kennedy, Robert F., Jr. (1 July 2005). "Autism, mercury and politics". Boston.com. Retrieved 19 October 2013.CS1 maint: multiple names: authors list (link)
  23. Olmsted, Dan (13 December 2004). "Study sees possible autism-vaccine link". United Press International. Retrieved 22 April 2014.
  24. Wasowicz, Lidia (3 November 2006). "Ped Med: Compelling clues to autism puzzle". UPI. Retrieved 24 March 2014.
  25. "Jane Botsford Johnson Foundation donates to Arkansas Children's Hospital for autism research". THV 11. 27 March 2012. Archived from the original on 14 December 2013. Retrieved 6 November 2013.
  26. James, S. J.; Slikker w, W.; Melnyk, S.; New, E.; Pogribna, M.; Jernigan, S. (2005). "Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors". NeuroToxicology. 26 (1): 1–8. doi:10.1016/j.neuro.2004.07.012. PMID 15527868.
  27. "New Thinking on Neurodevelopment". Autism Speaks. 8 October 2007. Retrieved 19 October 2013.
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