Jin Kim Montclare

Jin Kim Montclare is a Professor of Chemical and Biomolecular Engineering at New York University. She creates novel proteins that can be used in drug delivery, tissue regeneration and as medical treatment. She is a 2019 AAAS Leshner Leadership Fellow and has been inducted to the AIMBE College of Fellows.

Jin Kim Montclare
Jin Kim Montclare in 2017
Alma materFordham University
Yale University
Known forBiomolecular engineering
AwardsAAAS Leshner Fellow (2019)
Agnes Fay Morgan Research Award (2015)
Scientific career
InstitutionsCalifornia Institute of Technology
New York University
ThesisSpecific recognition of DNA by natural transcription factors and miniature protein mimics (2002)

Early life and education

Montclare was born in The Bronx. She is a first-generation Korean American.[1] She became interested in chemistry at high school.[2] She studied at Fordham University, where she majored in chemistry and minored in philosophy.[3] She earned her bachelor's degree in 1997.[1] She was awarded the Merck Index Award for excellence in organic chemistry and Clare Boothe Luce Scholarship for women in science. Montclare was elected a member of Iota Sigma Pi. She moved to Yale University for her graduate degree, earning master's in 2001 and a PhD in 2003. She worked in the lab of Alanna Schepartz, completing a thesis on the recognition of DNA by natural transcription factors.[4] Her graduate research was supported by National Science Foundation and Pfizer.[4] She attributes her passion for chemistry to her mentors, including her grandmother.

Research and career

Montclare joined California Institute of Technology as an National Institutes of Health postdoctoral fellow, where she began to work on engineering new molecules with David A. Tirrell.[5] She joined New York University in 2005, where she leads the Protein Engineering and Molecular Design Lab.[6][7]

Montclare has worked with the United States Department of Defense to detoxify organophosphates, which are commonly used in pesticides and as warfare agents.[8] She develops stable, activate fluorinated phosphotriesterase (PTE) variants by combining PTE with non-canonical amino acids.[9] She has also developed protein-engineered hydrogels that could be used as biomimetic materials.[10] Instead of synthetically creating polymers, Montclare uses biologically engineered proteins that can be easily controlled by external stimuli.[11] Montclare's protein-based hydrogels can be used to direct neuronal growth for brain augmentation.[12] The hydrogels could be used to heal wounds, sense or control the flow of fluids or deliver medicine.[11] They are made from Escherichia coli bacterium which are patterned onto substrates, similar to how geckos can adhere to surfaces.[11] The She has developed a range of other nanomaterials derived from proteins, including coiled-coil fibres and helix-elastin block polymers.[13][14]

Other research in the Montclare group includes the design of protein-lipid macromolecular systems that can be used to transport nanoparticles, drugs and genes to treat a variety of medical conditions.[10] The lipoprotoeplexes can be used to deliver drugs and genes across many types of cells in a GeneTrain.[15] They can form complexes with nucleic acid and small hydrophobic drugs.[16][17] The lipid container permits transfection past a cell membrane, whilst the protein capsule can bind chemotherapeutic molecules.[18]

Public engagement and advocacy

Montclare has been involved with outreach programs to introduce people in K-12 Education to science studies at the NYU Tandon School of Engineering.[19] She hosts a group of high school students for research opportunities every summer as well as leading outreach programs in Brooklyn high schools.[8] Montclare is part of the National Science Foundation Innovation Corps (I-Corps) program, and since 2013 has directed the New York University Tandon I-Corps site, the Convergence of Innovation and Entrepreneurship (CIE) Institute.[20][21][22] At the CIE Montclare seeks to increase the representation of women and underrepresented minority entrepreneurs, with the hope to increase their participation in STEM careers.[20] Whilst only 20% of engineering students in the United States are women, at New York University women make up between 40 and 45%.[23] She has written for The Huffington Post about the need for parents and adults to be more proactive in engaging their children with science.[24] Montclare co-founded inSchoolApps, who make web-based applications for science based applications.[23][25] Montclare was featured in the Marvel Comics Unstoppable Wasp.[26]

Awards and honours

Patents
  • 2008 Polymer carrier[34]
  • 2016 Protein engineered systems for delivery of molecules[35]
  • 2016 Fluorinated protein-based polymeric carriers[36]
  • 2017 Protein nanofibers from self-assembling pentamers[37]
  • 2017 Engineered fluorinated biomaterials[38]
  • 2017 Protein polymer gold nanoparticle hybrid materials for small molecule delivery[39]
  • 2017 Phosphotriesterase enzymes, methods and compositions related thereto[40]

References
  1. "2015 Morgan Research Award" (PDF). Iota Sigma Pi. Retrieved 2019-02-17.
  2. "Jin Montclare". STEM Women on Fire. Retrieved 2019-02-17.
  3. "Career Advice From Jin Montclare, Biochemist". Career Girls. Retrieved 2019-02-17.
  4. "Schepartz Laboratory | Intranet". schepartzlab.yale.edu. Retrieved 2019-02-17.
  5. "Speaker Bios – Nanoscience Initiative". Retrieved 2019-02-17.
  6. "Jin Kim Montclare | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  7. "Jin Montclare, NYU – Gene Therapy". academicminute.org. Retrieved 2019-02-17.
  8. "NYU Tandon Professor Named a Rising Star of Chemical Engineering | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  9. Montclare, Jin. "Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents". Cite journal requires |journal= (help)
  10. "NYU Tandon Professor Named to Elite" (PDF). NYU. Retrieved 2019-02-12.
  11. "Protein-engineered gels mimic body's own functions". Phys.org. Retrieved 2019-02-17.
  12. "Research Projects". Tumblr. Retrieved 2019-02-17.
  13. Dhabi, NYU Abu. "Speakers and Abstracts". New York University Abu Dhabi. Retrieved 2019-02-17.
  14. "NYU Positions Itself as a Leader in Biomedical Engineering | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  15. "NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells". News-Medical.net. 2015-09-11. Retrieved 2019-02-17.
  16. Hopkins, Author Mellissa (2017-09-18). "Women Behind Innovation: Jin Kim Montclare, PhD". Edison Awards News. Retrieved 2019-02-17.
  17. Liu, Che Fu; et al. (2017-08-04). "Efficient Dual siRNA and Drug Delivery Using Engineered Lipoproteoplexes". Biomacromolecules. 18 (9): 2688–2698. doi:10.1021/acs.biomac.7b00203. ISSN 1525-7797.
  18. "Biomaterial delivers both a powerful drug and gene silencers: New hybrid shows promise in dealing double blow to cancer cells by delivering both a chemotherapeutic agent and RNA interfering technology that silences drug resistance". ScienceDaily. Retrieved 2019-02-17.
  19. Siu, Diamond Naga. "Q&A: Tandon Professor a Rising Star in STEM | Washington Square News". Retrieved 2019-02-17.
  20. "NYU Tandon & NSF launch experiment to attract women & minorities to STEM entrepreneurship". EurekAlert!. Retrieved 2019-02-17.
  21. "Want to Start a Tech Business? With I-Corps, You Can | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  22. Montclare, Jin. "I-Corps: Lewis Dots 2.0". Cite journal requires |journal= (help)
  23. "Professor Jin Montclare Has Long Championed Women in STEM | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  24. Montclare, Jin Kim (2013-08-19). "Nurturing a STEM Sisterhood". HuffPost. Retrieved 2019-02-17.
  25. Patton, Madeline (2017-10-26). "The power of good mentors". Community College Daily. Retrieved 2019-02-17.
  26. "Unstoppable Wasp: Meeting of the Minds Pt. 2". Marvel Entertainment. Retrieved 2019-02-17.
  27. "Professor Montclare Receives Wechsler Award for Excellence | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  28. "Jin Kim Montclare Awarded Competitive Research Grant by Air Force | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  29. "NYU Tandon Teaching Awards | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
  30. Kretzschmar, Ilona (2018-01-23). "Spring 2018 Seminar Series - 01/29/18 | The City College of New York". www.ccny.cuny.edu. Retrieved 2019-02-17.
  31. Kretzschmar, Ilona (2018-01-23). "Spring 2018 Seminar Series - 01/29/18 | The City College of New York". www.ccny.cuny.edu. Retrieved 2019-02-17.
  32. "Incoming AAAS Leshner Fellows Focus on Human Augmentation". American Association for the Advancement of Science. Retrieved 2019-02-17.
  33. "NYU Tandon professor inducted into biomedical engineering elite". EurekAlert!. Retrieved 2019-03-27.
  34. Polymer carrier, retrieved 2019-02-17
  35. Protein engineered systems for delivery of molecules, retrieved 2019-02-17
  36. Fluorinated protein-based polymeric carriers, retrieved 2019-02-17
  37. Protein nanofibers from self-assembling pentamers, retrieved 2019-02-17
  38. Engineered fluorinated biomaterials, retrieved 2019-02-17
  39. Protein polymer gold nanoparticle hybrid materials for small molecule delivery, retrieved 2019-02-17
  40. Phosphotriesterase enzymes, methods and compositions related thereto, retrieved 2019-02-17
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