KDELR3

ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.[5]

KDELR3
Identifiers
Aliases	KDELR3, ERD2L3, KDEL endoplasmic reticulum protein retention receptor 3
External IDs	MGI: 2145953 HomoloGene: 68533 GeneCards: KDELR3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,468,078 bp[1] End 38,483,447 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,516,411 bp[2] End 79,527,739 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ER retention sequence binding • KDEL sequence binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • transport vesicle • Golgi membrane • endoplasmic reticulum • Golgi apparatus • cis-Golgi network • COPI-coated vesicle membrane • cytoplasmic vesicle Biological process • protein transport • protein retention in ER lumen • IRE1-mediated unfolded protein response • vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • ER to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11015	105785
Ensembl	ENSG00000100196	ENSMUSG00000010830
UniProt	O43731	Q8R1L4
RefSeq (mRNA)	NM_016657 NM_006855	NM_134090
RefSeq (protein)	NP_006846 NP_057839	NP_598851
Location (UCSC)	Chr 22: 38.47 – 38.48 Mb	Chr 15: 79.52 – 79.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.[5]

See also

• KDELR1
• KDELR2

References

1. GRCh38: Ensembl release 89: ENSG00000100196 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010830 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3".

Further reading

• Pelham HR (1997). "The dynamic organisation of the secretory pathway". Cell Struct. Funct. 21 (5): 413–9. doi:10.1247/csf.21.413. PMID 9118249.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.