KIF6

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene.[5] This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

KIF6
Identifiers
Aliases	KIF6, C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1, kinesin family member 6
External IDs	OMIM: 613919 MGI: 1098238 HomoloGene: 35308 GeneCards: KIF6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,329,990 bp[1] End 39,725,408 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 49,615,136 bp[2] End 49,909,847 bp[2]
Gene ontology Molecular function • microtubule binding • microtubule motor activity • nucleotide binding • ATPase activity • GO:0001948 protein binding • ATP binding Cellular component • cytoplasm • male germ cell nucleus • microtubules • cytoskeleton • kinesin complex Biological process • microtubule-based movement Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221458	319991
Ensembl	ENSG00000164627	ENSMUSG00000023999
UniProt	Q6ZMV9	n/a
RefSeq (mRNA)	NM_001289020 NM_001289021 NM_001289024 NM_145027 NM_001351503 NM_001351566	NM_177052
RefSeq (protein)	NP_001275949 NP_001275950 NP_001275953 NP_659464 NP_001338432 NP_001338495	n/a
Location (UCSC)	Chr 6: 39.33 – 39.73 Mb	Chr 17: 49.62 – 49.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000164627 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023999 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Kinesin family member 6".

Further reading

• Koroleva OS, Pushkov AA, Blagodatskikh KA, Baranova OA, Azizova OA, Nosikov VV, Reznichenko NE, Zateĭshchikov DA (2011). "[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease]". Kardiologiia. 51 (9): 4–12. PMID 21943003.
• Bare LA, Ruiz-Narvaéz EA, Tong CH, Arellano AR, Rowland CM, Catanese JJ, Sacks FM, Devlin JJ, Campos H (September 2010). "Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population". PLOS ONE. 5 (9): e13081. Bibcode:2010PLoSO...513081B. doi:10.1371/journal.pone.0013081. PMC 2947524. PMID 20927332.
• Peng P, Lian J, Huang RS, Xu L, Huang Y, Ba Y, Yang X, Huang X, Dong C, Zhang L, Ye M, Zhou J, Duan S (2012). "Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect". PLOS ONE. 7 (12): e50126. Bibcode:2012PLoSO...750126P. doi:10.1371/journal.pone.0050126. PMC 3517591. PMID 23236363.
• Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ (February 2012). "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly". Atherosclerosis. 220 (2): 456–62. doi:10.1016/j.atherosclerosis.2011.11.037. PMID 22192511.
• Liu X, Gomez-Pinillos A, Loder C, Carrillo-de Santa Pau E, Qiao R, Unger PD, Kurek R, Oddoux C, Melamed J, Gallagher RE, Mandeli J, Ferrari AC (September 2012). "KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation". The American Journal of Pathology. 181 (3): 1007–16. doi:10.1016/j.ajpath.2012.06.008. PMC 3432435. PMID 22819534.
• Davani S, Gozalo C, Gambert S, Chalmers D, Gambert P, Schiele F, Kantelip JP, Meneveau N (May 2010). "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction". Atherosclerosis. 210 (1): 48–50. doi:10.1016/j.atherosclerosis.2009.11.041. PMID 20044086.
• Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B (October 2010). "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients". Pharmacogenetics and Genomics. 20 (10): 634–7. doi:10.1097/FPC.0b013e32833de489. PMID 20679960. S2CID 3475599.
• Koroleva OS, Zateĭshchikov DA (2010). "[Motor protein Kinesin-6 and ischemic heart disease]". Kardiologiia. 50 (6): 54–62. PMID 20659029.
• Bhanushali AA, Contractor A, Shah VT, Das BR (December 2011). "Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians". Genetic Testing and Molecular Biomarkers. 15 (12): 883–6. doi:10.1089/gtmb.2011.0079. PMID 21810021.