Ken Hashimoto

Ken Hashimoto (橋本 健, June 19, 1931 – November 9, 2017) was a Japanese professor of dermatology resident in the United States, who pioneered research in skin disease using electron microscopy and histochemistry.

Ken Hashimoto
Born(1931-06-19)19 June 1931
Niigata City, Japan
Died9 November 2017(2017-11-09) (aged 86)
NationalityJapanese
EducationNiigata University
Medical career
ProfessionDermatology
InstitutionsWayne State University

He was born and brought up in Niigata City, Japan, where his father was professor and dean of the Niigata University School of Medicine. After graduating in medicine, he moved to the United States in 1956, and completed his training in dermatology at the University of Maryland and Massachusetts General Hospital.

He is best remembered for his skill in using the electron microscope and histochemistry to determine the pathogenesis of Anderson-Fabry's Disease. His name is connected with two rare skin conditions, congenital self-healing reticulohistiocytosis and the blistering transient bullous dermolysis of the newborn.

In 1980, he was appointed to Wayne State University as professor. Many future dermatologists were trained by him and he wrote numerous articles, book chapters and books.

Early life

Hashimoto was born on 19 June 1931,[1] and grew up in Niigata City, Japan. His father was professor and chair of dermatology, dean of the Niigata University School of Medicine, and president of the university, where Hashimoto also graduated in medicine. His brother also became a dermatologist.[2][3]

Career

In 1956, Hashimoto moved to the United States.[2] He was a Fulbright Scholar and did his residencies in dermatology at the University of Maryland and Massachusetts General Hospital.[2]

Research with electron microscope

In 1965, he wrote his classic paper on the pathogenesis of Anderson-Fabry's disease[4][5] where he demonstrated the use of an electron microscope to look at endothelial cells, smooth muscle cells, fibrocytes and perivascular cells in people with Fabry disease,[5] a lethal "metabolic disease angikeratoma corporis diffusum".[4] He confirmed the presence of large bodies in these cells which he described as “large residual bodies” [4] or "extremely overcrowded lysosomes",[5] and determined that a genetic abnormality caused a disturbance of lysosomal enzymes.[5]

Congenital self-healing reticulohistiocytosis[4] is also known as Hashimoto-Pritzker disease, first described by Hashimoto and Pritzker in 1973.[6] In addition, Transient bullous dermolysis of the newborn is named after Hashimoto who first described this condition with characteristic blister formations soon after birth, followed by rapid healing with or without scarring, in 1985.[4][7]

Wayne State University

He was appointed professor and chairman at Wayne State University in 1980, following faculty appointments at the University of Tennessee and Tufts University, and a position as chair of dermatology at Wright State University in Dayton, Ohio.[2][4]

Teaching and education

Hashimoto taught over one hundred resident physicians and forty research fellows.[2] He encouraged many researchers to work at his laboratory, of whom 15 rose to professorship in dermatology or anatomy in Japan.[3] In addition, he was supportive in alleviating the anxieties of Japanese dermatology students who travelled to the United States to study.[4]

He published 384 papers, just under 40 book chapters and eight books during his career,[2] including one in Japanese, the Histopathology of Skin Disease, the fifth volume of which remained unfinished at the time of his death.[3]

Together with his wife Noriko, he established the Hashimoto and Noriko Hashimoto Endowed Chair in the Department of Dermatology and Syphilology in 2007.[2]

Personal and family

Hashimoto was married to Noriko and they had four children, Naomi, Martha, Eugene and Amy.[3]

Throughout his time in Memphis, Tennessee, Hashimoto enjoyed fishing and his motorboat, which he would drive to local rivers and lakes for an annual trip to the Gulf of Mexico.[3] He also liked gardening and planting fruit trees.[2] His other hobbies included farming and later feeding several types of birds in his backyard,[3] including ducks, pheasants and peafowl.[2] In addition, he used some of his retirement to travel frequently to Japan.[4]

Death and legacy

For many years Hashimoto suffered from recurrent falls and aspiration due to Parkinson's Disease.[8] Hashimoto died on 9 November 2017, at the age of 86 years, at his home in Ann Arbor, Michigan.[3] He was survived by his wife, two sisters, one brother, four children and nine grandchildren.[2]

Selected publications

Books
  • Skin Pathology by Light and Electron Microscopy. Igaku-Shoin, New York, 1983. (With Kan Niizuma) ISBN 9780896400801
  • Tumors of Skin Appendages. Butterworths, 1987. (With Amir H. Mehregan and Masanobu Kumakiri) ISBN 9780409951592
  • Tumors of the Epidermis. Butterworths, c.1990. (With Amir H. Mehregan) ISBN 0409901636

Book chapters
  • "Immunohistochemical Diagnosis of Skin Tumors", with M. Setoyama and E. Hashimoto, in Randall K. Roenigk & Henry H. Roenigk Jr. (Eds.) Surgical Dermatology: Advances in Current Practice. Martin Dunitz, London, 1993. pp. 131–138. ISBN 185317-061-5.

Articles

References
  1. "Ken Hashimoto Obituary - Ann Arbor, MI | Livingston Daily Press & Argus". legacy.com. Retrieved 9 August 2018.
  2. "Services scheduled for Ken Hashimoto, M.D., retired Dermatology chair « News". www.med.wayne.edu. Retrieved 9 August 2018.
  3. Kanzaki, Tamotsu (February 2018). "Ken Hashimoto, M.D., Ph.D. (1931-2017): A tribute". The Journal of Dermatology. 45 (2): 121. doi:10.1111/1346-8138.14212. ISSN 1346-8138.
  4. John Thorne Crissey; Lawrence C. Parish; Karl Holubar (2013). Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 179. ISBN 978-1-84214-100-7.
  5. Mehta, Atul; Beck, Michael; Linhart, Aleš; Sunder-Plassmann, Gere; Widmer, Urs (2006), Mehta, Atul; Beck, Michael; Sunder-Plassmann, Gere (eds.), "History of lysosomal storage diseases: an overview", Fabry Disease: Perspectives from 5 Years of FOS, Oxford PharmaGenesis, ISBN 978-1903539033, PMID 21290707, retrieved 9 August 2018
  6. Lee, Young H.; Talekar, Mala K.; Chung, Catherine G.; Bell, Moshe D.; Zaenglein, Andrea L. (February 2014). "Congenital Self-Healing Reticulohistiocytosis". The Journal of Clinical and Aesthetic Dermatology. 7 (2): 49–53. ISSN 1941-2789. PMC 3935651. PMID 24578781.
  7. Murase, K; Kanoh, H; Ishii, N; Hashimoto, T; Nakano, H; Sawamura, D; Seishima, M (2011). "Bullous Dermolysis of the Newborn and Dystrophic Epidermolysis Bullosa Pruriginosa within the Same Family: Two Phenotypes Associated with a COL7A1 Mutation". Acta Dermato Venereologica. 91 (6): 730–731. doi:10.2340/00015555-1154. ISSN 0001-5555. PMID 21629976.
  8. Ken Hashimoto. Michael J. Fox Foundation. Retrieved 10 August 2018.
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