Krishna Kumar (chemist)

Krishna Kumar (born 1 November 1970) is an Indian American chemist whose research spans organic chemistry, chemical biology, bioorganic chemistry, biophysics and cell biology. He is currently Robinson Professor of Chemistry and was also Chemistry Department Chair from 2006 to 2009; and from 2012 to 2018 at Tufts University.

Krishna Kumar
Born (1970-11-01) 1 November 1970
Madras, Tamil Nadu, India
NationalityAmerican
Alma materSt. Stephen's College, Delhi
Brown University
The Scripps Research Institute
Scientific career
FieldsChemical biology, Biophysics, Organic chemistry
InstitutionsTufts University
ThesisThrough Solvent Electron Transfer in Molecular C-Clamps (1996)
Doctoral advisorMatthew B. Zimmt
Other academic advisorsM. Reza Ghadiri

Career

Prior to Tufts University, he was at the Scripps Research Institute in La Jolla, California and got his bachelor's degree in Chemistry with honors from St. Stephen's College, Delhi and a Ph.D. degree in Chemistry (1996) from Brown University.

Kumar has given proteins hyperstable folding properties by inserting fluorinated amino acids into them. Recent studies by his research team have shown that fluorination of biologically active antimicrobial peptides is an effective strategy for improving their stability and antimicrobial therapeutic value.

In addition to antibiotics, Kumar's work includes the design of fluorinated drug delivery systems using lipids as carriers, and potential cancer drugs and imaging agents. His laboratory has also invented methods for cell surface engineering and imaging of cancer cells with metastatic potential.

Awards, honors, affiliations and positions

Publications

Web of Science shows these as the 10 most cited publications:

  1. Bilgiçer, B.; Fichera, A.; Kumar, K. "A Coiled Coil with a Fluorous Core."J. Am. Chem. Soc. 2001, 123, 4393-4399. Discussed by : "Fluorous Peptides." by Stu Borman, C&EN 2001, 79(20), 41-42; "Heart Cut" Chemical Innovation 2001, 31 (11), pp. 10. ; "Steps Towards Nanotechnology" by Jeffrey Soreff, Institute for Molecular Manufacturing (IMM), IMM Report No. 26, 23 October 2001.
  2. Bilgiçer, B.; Xing, X.; Kumar, K. "Programmed Self-Sorting of Coiled Coils with Leucine and Hexafluoroleucine Cores." J. Am. Chem. Soc. 2001, 123, 11815-11816. Discussed by: Science & Technology Roundup, C&EN 2001, 79 (49), p. 35.
  3. Yoder, N. C.; Kumar, K. "Fluorinated Amino Acids in Protein Design and Engineering." Chem. Soc. Rev. 2002, 31, 335-341.
  4. Bilgicer B, Kumar K "Synthesis and thermodynamic characterization of self-sorting coiled coils " Tetrahedron 2002 58( 20) 4105-4112.
  5. Bilgiçer, B.; Kumar, K. "De Novo Design of Defined Helical Bundles in Membrane Environments." Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 15324-15329.
  6. Myers, K. E.; Kumar, K. "Fluorophobic Acceleration of Diels-Alder Reactions." J. Am. Chem. Soc. 2000, 122, 12025-12026.
  7. Xing, X.; Fichera, A.; Kumar, K. "A Novel Synthesis of Enantiomerically Pure 5,5,5,5',5',5'–Hexafluoroleucine." Org. Lett. 2001, 3, 1285-1286.
  8. Meng, H.; Kumar, K. "Antimicrobial Activity and Protease Stability of Peptides Containing Fluorinated Amino Acids" J. Am. Chem. Soc. 2007, 129, 15615-15622. Discussed by: "Fluorous Peptides Get Ready to Heal" by Stephen Ritter, C&EN 2007, 85 (37), pp. 36–37; "Putting the "F" in peptides" by Randall C Willis; Drug Discovery News 2007, December.
  9. Montanari V.; Kumar, K. "Just Add Water: A New Fluorous Capping Reagent for Facile Purification of Peptides Synthesized on the Solid Phase." J. Am. Chem. Soc. 2004, 126, 9528-9529.
  10. Wang P, Fichera A, Kumar K, et al. "Alternative translations of a single RNA message: An identity switch of (2S,3R)-4,4,4-trifluorovaline between valine and isoleucine codons " (2004)Angewandte Chemie International Ed. 43 (28) 3664-3666.

References
  1. "MIT Technovators awards for 10 Indians". The Economic Times. 5 December 2006. Archived from the original on 28 January 2007. Retrieved 2 January 2010.
  2. "Two Indians receive 2006 Global Indus Technovators Awards". PTI - The Press Trust of India Ltd. 4 December 2006. Retrieved 2 January 2010.
  3. "TR35 2003 Young Innovator: Krishna Kumar, 32". Technology Review. 2003. Retrieved 2 January 2010.
  4. Mehta, Ruchika (26 September 2003). "Indian innovators shine globally". Times of India. Asia Africa Intelligence Wire. Retrieved 2 January 2010.
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