LCP1

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[5]

LCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D85
Identifiers
Aliases	LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
External IDs	OMIM: 153430 MGI: 104808 HomoloGene: 80174 GeneCards: LCP1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.13 Start 46,125,920 bp[1] End 46,211,871 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D3|14 39.63 cM Start 75,131,101 bp[2] End 75,230,842 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding • actin filament binding • identical protein binding • GTPase binding • actin binding • integrin binding Cellular component • cytoplasm • cytosol • cell projection • membrane • focal adhesion • filopodium • ruffle • cell membrane • stress fiber • ruffle membrane • actin filament • actin cytoskeleton • actin filament bundle • podosomes • phagocytic cup • extracellular exosome • cytoskeleton • extracellular • cell junction • perinuclear region of cytoplasm Biological process • extracellular matrix disassembly • positive regulation of podosome assembly • actin filament bundle assembly • regulation of intracellular protein transport • animal organ regeneration • protein kinase A signaling • cell migration • wound healing, spreading of cells • T cell activation involved in immune response • actin filament network formation • actin crosslink formation • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3936	18826
Ensembl	ENSG00000136167	ENSMUSG00000021998
UniProt	P13796	Q61233
RefSeq (mRNA)	NM_002298	NM_001247984 NM_008879
RefSeq (protein)	NP_002289 NP_002289.2	NP_001234913 NP_032905
Location (UCSC)	Chr 13: 46.13 – 46.21 Mb	Chr 14: 75.13 – 75.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136167 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021998 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (January 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166.
6. "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)".

Further reading

• Namba Y, Ito M, Zu Y, Shigesada K, Maruyama K (October 1992). "Human T cell L-plastin bundles actin filaments in a calcium-dependent manner". Journal of Biochemistry. 112 (4): 503–7. doi:10.1093/oxfordjournals.jbchem.a123929. PMID 1491005.
• Zu YL, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, Namba Y (September 1990). "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites". Biochemistry. 29 (36): 8319–24. doi:10.1021/bi00488a017. PMID 2252891.
• Lin CS, Aebersold RH, Leavitt J (April 1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain". Molecular and Cellular Biology. 10 (4): 1818–21. doi:10.1128/MCB.10.4.1818. PMC 362293. PMID 2378651.
• Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J (November 1988). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts". Molecular and Cellular Biology. 8 (11): 4659–68. doi:10.1128/MCB.8.11.4659. PMC 365555. PMID 3211125.
• Matsushima K, Shiroo M, Kung HF, Copeland TD (May 1988). "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1". Biochemistry. 27 (10): 3765–70. doi:10.1021/bi00410a037. PMID 3261603.
• Kondo I, Shin K, Honmura S, Nakajima H, Yamamura E, Satoh H, Terauchi M, Usuki Y, Takita H, Hamaguchi H (1986). "A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13". Human Genetics. 71 (3): 263–6. doi:10.1007/BF00284588. PMID 3864729.
• Arpin M, Friederich E, Algrain M, Vernel F, Louvard D (December 1994). "Functional differences between L- and T-plastin isoforms". The Journal of Cell Biology. 127 (6 Pt 2): 1995–2008. doi:10.1083/jcb.127.6.1995. PMC 2120298. PMID 7806577.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Lin CS, Shen W, Chen ZP, Tu YH, Matsudaira P (April 1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney". Molecular and Cellular Biology. 14 (4): 2457–67. doi:10.1128/mcb.14.4.2457. PMC 358613. PMID 8139549.
• Lin CS, Park T, Chen ZP, Leavitt J (February 1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells". The Journal of Biological Chemistry. 268 (4): 2781–92. PMID 8428952.
• Lin CS, Chen ZP, Park T, Ghosh K, Leavitt J (February 1993). "Characterization of the human L-plastin gene promoter in normal and neoplastic cells". The Journal of Biological Chemistry. 268 (4): 2793–801. PMID 8428953.
• Jones SL, Brown EJ (June 1996). "FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils". The Journal of Biological Chemistry. 271 (24): 14623–30. doi:10.1074/jbc.271.24.14623. PMID 8663066.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H (January 1999). "The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin". FEBS Letters. 442 (1): 39–42. doi:10.1016/S0014-5793(98)01612-3. PMID 9923600.
• Wang J, Brown EJ (August 1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A". The Journal of Biological Chemistry. 274 (34): 24349–56. doi:10.1074/jbc.274.34.24349. PMID 10446213.
• Lin CS, Lau A, Yeh CC, Chang CH, Lue TF (January 2000). "Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences". DNA and Cell Biology. 19 (1): 1–7. doi:10.1089/104454900314654. PMID 10668786.
• Jia J, Han Q, Borregaard N, Lollike K, Cygler M (July 2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". Journal of Molecular Biology. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
• Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA (May 2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". The Journal of Biological Chemistry. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.