LHX2

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.[5][6][7]

LHX2
Identifiers
Aliases	LHX2, LH2, hLhx2, LIM homeobox 2
External IDs	OMIM: 603759 MGI: 96785 HomoloGene: 55848 GeneCards: LHX2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 124,001,670 bp[1] End 124,033,301 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 38,339,281 bp[2] End 38,369,733 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • sequence-specific DNA binding • chromatin binding • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • RNA polymerase II regulatory region sequence-specific DNA binding Cellular component • cell nucleus • intracellular Biological process • negative regulation of transcription regulatory region DNA binding • mesoderm development • telencephalon development • neural tube closure • retina development in camera-type eye • cerebral cortex development • transcription, DNA-templated • axon guidance • axon extension • hair follicle development • maintenance of epithelial cell apical/basal polarity • neurogenesis • brain development • olfactory bulb development • nervous system development • dorsal/ventral pattern formation • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • neuron differentiation • anatomical structure formation involved in morphogenesis • telencephalon regionalization • transcription from RNA polymerase II promoter • negative regulation of gene expression, epigenetic • negative regulation of neurogenesis • positive regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9355	16870
Ensembl	ENSG00000106689	ENSMUSG00000000247
UniProt	P50458	Q9Z0S2
RefSeq (mRNA)	NM_004789	NM_001290646 NM_010710
RefSeq (protein)	NP_004780	NP_001277575 NP_034840
Location (UCSC)	Chr 9: 124 – 124.03 Mb	Chr 2: 38.34 – 38.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.[7]

Interactions

LHX2 has been shown to interact with CITED2.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD (July 1996). "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1". Oncogene. 12 (6): 1205–1212. PMID 8649822.
6. Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J (April 1999). "Conservation of the expression and function of apterous orthologs in Drosophila and mammals". Proc Natl Acad Sci U S A. 96 (5): 2165–2170. Bibcode:1999PNAS...96.2165R. doi:10.1073/pnas.96.5.2165. PMC 26754. PMID 10051612.
7. "Entrez Gene: LHX2 LIM homeobox 2".
8. Glenn, D J; Maurer R A (December 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. UNITED STATES. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–36167. doi:10.1074/jbc.274.51.36159. PMID 10593900.
• Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–399. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
• Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C (1998). "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity". Differentiation. 63 (3): 151–157. doi:10.1046/j.1432-0436.1998.6330151.x. PMID 9697309.