LIME1

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene.[5][6]

LIME1
Identifiers
Aliases	LIME1, LIME, LP8067, dJ583P15.4, Lck interacting transmembrane adaptor 1
External IDs	OMIM: 609809 MGI: 1919949 HomoloGene: 56785 GeneCards: LIME1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,736,283 bp[1] End 63,739,103 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,380,078 bp[2] End 181,383,628 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase binding Cellular component • integral component of membrane • cell membrane • membrane • extracellular • U2-type post-mRNA release spliceosomal complex • B cell receptor complex Biological process • B cell receptor signaling pathway • T cell receptor signaling pathway • adaptive immune response • immune system process • spliceosomal complex disassembly • regulation of transcription from RNA polymerase II promoter • regulation of phosphatidylinositol 3-kinase signaling • regulation of I-kappaB kinase/NF-kappaB signaling • regulation of MAP kinase activity • regulation of release of sequestered calcium ion into cytosol • regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54923	72699
Ensembl	ENSG00000203896	ENSMUSG00000090077
UniProt	Q9H400	Q9EQR5
RefSeq (mRNA)	NM_017806 NM_001305654 NM_001305655	NM_023684
RefSeq (protein)	NP_001292583 NP_001292584 NP_060276	NP_076173
Location (UCSC)	Chr 20: 63.74 – 63.74 Mb	Chr 2: 181.38 – 181.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003; Hur et al., 2003).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000203896 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090077 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1".

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Hur EM, Son M, Lee OH, et al. (2004). "LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation". J. Exp. Med. 198 (10): 1463–73. doi:10.1084/jem.20030232. PMC 2194117. PMID 14610044.
• Brdicková N, Brdicka T, Angelisová P, et al. (2004). "LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling". J. Exp. Med. 198 (10): 1453–62. doi:10.1084/jem.20031484. PMC 2194115. PMID 14610046.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
• Ahn E, Lee H, Yun Y (2006). "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation". Blood. 107 (4): 1521–7. doi:10.1182/blood-2005-05-1859. PMID 16249387.