LRCH4

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.[5][6]

LRCH4
Identifiers
Aliases	LRCH4, LRN, LRRN1, LRRN4, PP14183, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4
External IDs	MGI: 1917193 HomoloGene: 20532 GeneCards: LRCH4
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,574,011 bp[1] End 100,586,129 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,629,121 bp[2] End 137,641,099 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • PML body • cytoplasm • basolateral plasma membrane Biological process • nervous system development • signal transduction • maintenance of epithelial cell apical/basal polarity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4034	231798
Ensembl	ENSG00000077454	ENSMUSG00000093445
UniProt	O75427	Q921G6
RefSeq (mRNA)	NM_002319 NM_001289934	NM_001168652 NM_146164
RefSeq (protein)	NP_001276863 NP_002310	NP_001162123 NP_666276
Location (UCSC)	Chr 7: 100.57 – 100.59 Mb	Chr 5: 137.63 – 137.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000077454 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000093445 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
6. "Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Shiio Y, Rose DW, Aur R, et al. (2006). "Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex". Mol. Cell. Biol. 26 (4): 1386–97. doi:10.1128/MCB.26.4.1386-1397.2006. PMC 1367179. PMID 16449650.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.