Leslie Z. Benet

Leslie 'Les' Zachary Benet (born May 17, 1937) is an influential pharmaceutical scientist[1] heading the UCSF's Benet Lab at the Department of Bioengineering and Therapeutic Sciences[2] and recipient of the Remington Medal for distinguished service to American pharmacy.

Leslie Z. Benet
BornMay 17, 1937 (1937-05-17) (age 83)
Cincinnati, Ohio
OccupationUCSF (Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry)
TitleProfessor
Spouse(s)Carol
Academic background
Alma materUniversity of California
ThesisThermodynamics of Chelation by Tetracyclines (1965)
Doctoral advisorJere Goyan
Academic work
DisciplinePharmacology
Sub-disciplinePharmacokinetics, Pharmacodynamics, Bioequivalence
InstitutionsWashington State University, University of California
Websiteprofiles.ucsf.edu/leslie.benet

Early life and education

Leslie Zachary Benet was born on May 17, 1937 in Cincinnati, Ohio into a family of pharmacists. His father, Jonas and his uncle, Harry, opened Benet's Pharmacies in Cincinnati in the 1930s and in 1942 founded DARA Products, the first drug company to manufacture hypoallergenic dermatologicals.[3]

Benet received his B.A. (English, 1959), B.S. (Pharmacy, 1960), M.S. (Pharmaceutical Chemistry, 1962) from the University of Michigan and Ph.D. (Pharmaceutical Chemistry, 1965) from the University of California.[3]

Academic career

Benet's early work included noncompartmental methods for calculating clearance and volume of distribution.[4][5][6] His paper on the volume of distribution is the most highly cited article in the Journal of Pharmaceutical Sciences (cited more than 900 times out of 19,000 articles).[7] In 1986 he was a founder and first president of the American Association of Pharmaceutical Scientists.[8] For over twenty years, Benet chaired the Department of Pharmacy at the UCSF which, under his leadership, became the Department of Biopharmaceutical Sciences. He supervised more than 55 Ph.D. theses and 100 post-doc students. Benet regularly advised the FDA in proposing guidance in the field of bioequivalence.[9] His recent work extended the Biopharmaceutics Classification System, leading to the Biopharmaceutics Drug Disposition Classification System allowing the prediction of enzymes and transporters, transporter-enzyme interplay and transporter-transporter interplay for new molecular entities and drug-drug interactions for already marketed drugs.[10][11] Benet is listed as one of the "25 Top Pharmacy Professors" in the USA.[12]

Published works

Benet published over 550 articles in peer-reviewed journals, more than 100 book chapters, and seven books.

Honors and awards

Honorary degrees
  • Uppsala University, Sweden (FarmDhc., 1987)[13]
  • Leiden University, The Netherlands (Ph.D., 1995)
  • University of Illinois at Chicago (D.Sc., 1997)
  • Philadelphia College of Pharmacy and Science (D.Sc., 1997)
  • Long Island University (D.Sc., 1999)
  • University of Athens, Greece (Ph.D., 2005)
  • Catholic University of Leuven, Belgium (Ph.D., 2010)
  • University of Michigan (D.Sc., 2011)
  • University of Lisbon, Portugal (Ph.D., 2016)

Scientific/professional honors and awards
  • Distinguished Alumnus Award (University of Michigan College of Pharmacy, 1982)
  • Research Achievement Award in Pharmaceutics (Academy of Pharmaceutical Sciences, 1982)
  • Distinguished Service Award (ACCP, 1988)
  • Distinguished Scientist Award (AAPS, 1989)
  • Rho Chi Society Lecture Award (The Rho Chi Society, 1990)
  • Volwiler Distinguished Research Achievement Award (AACP, 1991)
  • Distinguished Service Profile Award (American Foundation for Pharmaceutical Education, 1993)
  • Rawls-Palmer Progress in Medicine Award (American Society for Clinical Pharmacology and Therapeutics, 1995)
  • Distinguished Service Award (AAPS, 1996)
  • Takeru Higuchi Research Prize (APhA, 2000)
  • Wurster Research Award in Pharmaceutics (AAPS, 2000)
  • Høst-Madsen Medal (FIP, 2001)
  • Research Achievement Award in Pharmaceutical Sciences (Pharmaceutical Sciences World Congress, 2004)
  • Career Achievement Award in Oral Drug Delivery (Controlled Release Society, 2004)
  • Paul Ehrlich Magic-Bullet Lifetime Achievement Award (Nürnberg, Germany, 2008)
  • Oscar B. Hunter Memorial Award in Therapeutics (American Society for Clinical Pharmacology and Therapeutics, 2010)
  • Distinguished Investigator Award (ACCP, 2011)
  • APhA-APRS Ebert Prize[14] (American Pharmacists Association – Academy of Pharmaceutical Research and Science, 2013)
  • North American Scientific Achievement Award (International Society for the Study of Xenobiotics, 2015)
  • Remington Medal (2016)

Teaching awards
  • Academic Senate Distinguished Teaching Award (UCSF, 1973)
  • Long Teaching Award for Excellence in Teaching (UCSF School of Pharmacy, 1990)
  • Outstanding Faculty Mentorship Award (UCSF Graduate Division, 2001 and 2016)

References
  1. Faculdade de Farmácia (March 31, 2016). "Leslie Benet" (PDF) (in Portuguese). Universidade de Lisboa. Retrieved June 13, 2016.
  2. "Benet Lab". University of California, San Francisco. Retrieved May 4, 2018.
  3. Smith, David E.; Rowland, Malcolm; Giacomini, Kathleen M.; Amidon, Gordon L (July 20, 2012). "Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong!" (PDF). Pharmaceutical Research. 29 (9): 2345–2353. doi:10.1007/s11095-012-0808-3. PMID 22814901. S2CID 13303011. Retrieved May 20, 2016.
  4. Rowland, Malcolm; Benet, Leslie Z.; Graham, Garry G. (April 1973). "Clearance Concepts in Pharmacokinetics". Journal of Pharmacokinetics and Biopharmaceutics. 1 (2): 123–136. doi:10.1007/BF01059626. PMID 4764426. S2CID 9361701.
  5. Benet, Leslie Z.; Galeazzi, Renato L. (August 1979). "Noncompartmental Determination of the Steady- State Volume of Distribution" (PDF). Journal of Pharmaceutical Sciences. 68 (8): 1071–1074. doi:10.1002/jps.2600680845. PMID 480170. Retrieved May 20, 2016.
  6. Benet, Leslie Z. (February 3, 2012). "Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory". The AAPS Journal. 14 (2): 164–167. doi:10.1208/s12248-012-9326-9. PMC 3326156. PMID 22302585.
  7. Hammerlund-Udanaes, Margareta; Brouwer, Kim; Nakashima, Emi; Terasaki, Tetsuya (June 6, 2013). "Perspectives on a Pharmacokinetics Legend: C versus T (Contributions over Time)". Journal of Pharmaceutical Sciences. 102 (9): 2889–2894. doi:10.1002/jps.23628. PMID 23744575.
  8. Benet, Leslie (November 2013). I Am AAPS (Speech). 2013 AAPS Annual Meeting and Exposition. San Antonio, TX: AAPS (published Feb 5, 2014). Retrieved May 20, 2016.
  9. "Pharmaceutical Science and Clinical Pharmacology Advisory Committee". Food and Drug Administration. March 29, 2016. Retrieved May 20, 2016.
  10. Wu, Chi-Yuan; Benet, Leslie Z. (January 1, 2005). "Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System". Pharmaceutical Research. 22 (1): 11–23. doi:10.1007/s11095-004-9004-4. PMID 15771225. S2CID 2505634.
  11. Benet, Leslie Z.; Broccatelli, Fabio; Oprea, Tudor I. (August 5, 2011). "BDDCS Applied to Over 900 Drugs". The AAPS Journal. 13 (4): 519–547. doi:10.1208/s12248-011-9290-9. PMC 3231854. PMID 21818695.
  12. Franklin, Barry (2016). "25 Top Pharmacy Professors". Medical Technology Schools. Retrieved May 20, 2016.
  13. "Honorary doctorates - Uppsala University, Sweden".
  14. Reyes, Maribel; Benet, Leslie Z. (September 2011). "Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics" (PDF). Journal of Pharmaceutical Sciences. 68 (8): 3831–3842. doi:10.1002/jps.22640. PMC 3581075. PMID 21618544. Retrieved May 20, 2016.
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