Lisa Jones (scientist)

Lisa M. Jones is an associate professor of pharmaceutical sciences at the University of Maryland, Baltimore.[1]

Lisa Jones
Alma materSyracuse University
Georgia State University
Known forCell footprinting
Scientific career
InstitutionsUniversity of Maryland

Indiana University-Purdue University Indianapolis

Washington University

Early life and education

Jones became interested in science as a freshman at high school, where she took part in a national Science Technology Engineering Program.[2] She went to college at Syracuse University, where she was the only person of colour.[3] Jones completed her PhD at Georgia State University and specialized in structural biology.[4]

Research and career

She was a Pfizer postdoctoral researcher at Washington University in St. Louis.[5][2] She joined Indiana University – Purdue University Indianapolis, where she became an associate professor.[6][7] In 2016 Jones won a $1.1 million National Science Foundation Career grant to develop new techniques to study cell membranes.[2] Her award supported research training for students from historically black colleges and universities to work in biochemistry.[2] She developed cell-footprinting, a technique that uses mass spectrometry coupled with in vivo fast photochemical oxidation of proteins (FPOP).[2][8][9] She is recognised for solving new questions in medicine as well as developing important tools for biomedical researchers.[7]

She moved to the University of Maryland School of Pharmacy in 2016.[10] The Jones Lab is a structural proteomics group, who specialist in FPOP using an excimer laser for photolysis, which generates hydroxyl radicals.[11] Hydroxyl radicals go on to oxidise the side chains of amino acids and provide solvent accessibility of proteins within a cell.[12] FPOP can provide information on the sites of ligand binding, protein interaction and protein conformational changes in vivo.[11] Her group has continued to develop the FPOP technique, extending it with a no-flow platform for high-throughput in-cell measurements.[13] In 2019, she received the Biophysical Society's Junior Faculty Award.[14]

References
  1. "Lisa Jones". Retrieved 19 October 2020.
  2. "IUPUI chemist receives $1.1M NSF grant for research, training of minority future researchers: Newscenter: Indiana University–Purdue University Indianapolis". archive.news.iupui.edu. Retrieved 2018-04-22.
  3. @Victoria08Davis, VICTORIA T. DAVIS. "IUPUI chemist awarded more than $1 million for research, training of minority students". Indianapolis Recorder Newspaper. Retrieved 2018-04-22.
  4. Chea, Emily E.; Jones, Lisa M. (2018-02-12). "Analyzing the structure of macromolecules in their native cellular environment using hydroxyl radical footprinting". Analyst. 143 (4): 798–807. Bibcode:2018Ana...143..798C. doi:10.1039/C7AN01323J. ISSN 1364-5528. PMID 29355258.
  5. Jones, Lisa M.; Zhang, Hao; Vidavsky, Ilan; Gross, Michael L. (2010-02-15). "An On-Line, High-Pressure Digestion System for Protein Characterization by Hydrogen/Deuterium Exchange and Mass Spectrometry". Analytical Chemistry. 82 (4): 1171–1174. doi:10.1021/ac902477u. PMC 2826105. PMID 20095571.
  6. "Lisa Jones". stem.indiana.edu. Retrieved 2018-04-22.
  7. Brown, Alex. "IUPUI Professor Receives Lucrative Award". Retrieved 2018-04-22.
  8. "NSF Award Search: Award#1701692 - CAREER: Development of an In Cell Footprinting Method for the Analysis of Protein Structure". www.nsf.gov. Retrieved 2018-04-22.
  9. Rinas, Aimee; Mali, Vishaal S.; Espino, Jessica A.; Jones, Lisa M. (2016-10-07). "Development of a Microflow System for In-Cell Footprinting Coupled with Mass Spectrometry". Analytical Chemistry. 88 (20): 10052–10058. doi:10.1021/acs.analchem.6b02357. PMID 27681498.
  10. "Its official! We're getting FPOP in Baltimore!". proteomicsnews.blogspot.co.uk. 2016-06-11. Retrieved 2018-04-22.
  11. "Lisa Jones". faculty.rx.umaryland.edu. Retrieved 2018-04-22.
  12. "Professor Lisa Jones - Indiana University" (PDF). University of Toledo. 2014-09-24. Retrieved 2018-04-22.
  13. "Proteomic Mass Spec Assesses Biomolecular Teamwork". Genetic Engineering and Biotechnology News. 2020-05-04. Retrieved 2020-06-12.
  14. "PSC Researcher Awarded Biophysical Society's Junior Faculty Award". University of Maryland School of Pharmacy. 2019-03-06. Retrieved 2020-06-12.
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