List of adaptins

Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes.[1] There are several types of adaptin, each related to a different AP complex.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.[1] The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):

• complex 1
  • AP1B1
  • AP1G1
  • AP1G2
  • AP1M1
  • AP1M2
  • AP1S1
  • AP1S2
  • AP1S3
• complex 2
  • AP2A1
  • AP2A2
  • AP2B1
  • AP2M1
  • AP2S1
• complex 3
  • AP3B1
  • AP3B2
  • AP3D1
  • AP3M1
  • AP3M2
  • AP3S1
  • AP3S2
• complex 4
  • AP4B1
  • AP4E1
  • AP4M1
  • AP4S1
• complex 5[2]
  • AP5Z1
  • AP5B1
  • AP5M1
  • AP5S1

A diagram of the 5 complexes is shown here

References

1. Boehm, Markus; Bonifacino, Juan S. (October 2001). "Adaptins". Molecular Biology of the Cell. 12 (10): 2907–2920. doi:10.1091/mbc.12.10.2907. ISSN 1059-1524. PMC 60144. PMID 11598180.
2. Mattera, Rafael; Guardia, Carlos M.; Sidhu, Sachdev S.; Bonifacino, Juan S. (2015). "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal of Biological Chemistry. 290 (52): 30736–30749. doi:10.1074/jbc.M115.683409. PMC 4692204. PMID 26542808.

• Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
• Hirst, J. D.; Barlow, L; Francisco, GC; Sahlender, DA; Seaman, MNJ; Dacks, JB; et al. (2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10): e1001170. doi:10.1371/journal.pbio.1001170. PMC 3191125. PMID 22022230.