List of cutaneous conditions associated with internal malignancy

There are many skin conditions that may occur which are associated with cancers, as well as some benign tumors, inside the human body.

Cutaneous conditions associated with internal benign tumors and/or malignancies
Cutaneous conditionInternal malignancy
Erythema gyratum repensLung cancer
Hypertrichosis lanuginosa acquisitaLung cancer
Paraneoplastic pemphigusNon-Hodgkin lymphoma[nb 1]
Chronic lymphocytic leukemia
Castleman's disease[nb 1]
Sarcoma
Thymoma
Tripe palmsLung cancer
Tripe palms with acanthosis nigricansStomach cancer
Pityriasis rotunda Hepatocellular carcinoma
Migratory thrombophlebitis Pancreatic adenocarcinoma
Acanthosis palmaris Bronchial carcinoma
Sign of Leser–Trélat Gastrointestinal adenocarcinoma
Acquired ichthyosis Hodgkin disease
Pityriasis rotunda Hepatocellular carcinoma
Paraneoplastic pigmentation Small cell bronchial carcinoma
Acrokeratosis paraneoplastica Squamous cell carcinoma of the upper respiratory or gastrointestinal

tracts

Necrolytic migratory erythema Glucagon secreting

pancreatic islet cell adenoma

Dermatomyositis Lung cancer in men, breast and gynaecological tumours in women and colorectal cancers in both sexes
Scleroderma‐like skin changes Carcinoid syndrome
Paraneoplastic pemphigus B‐cell proliferations and thymoma or thymoma‐like neoplasms; specifically Non Hodgkin's lymphoma (42%)
Dermatitis herpetiformis Lymphoma
Porphyria cutanea tarda and variegate porphyrias Hepatocellular Carcinoma
Erythroderma and exfoliative dermatitis Mycosis fungoides or Sézary syndrome
Pyoderma gangrenosum Hematological malignancy
Sweet syndrome Hematological malignancy
This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

Footnotes
  1. Non-Hodgkin lymphoma is the most common cause of paraneoplastic pemphigus in adults. Castleman's disease is the most common cause of paraneoplastic pemphigus in children.

See also

References
    • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0.
    • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
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