MEX3D

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[5][6]

MEX3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGR
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	OMIM: 611009 MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,554,669 bp[1] End 1,568,058 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,380,355 bp[2] End 80,387,659 bp[2]
Gene ontology Molecular function • AU-rich element binding • metal ion binding • nucleic acid binding • RNA binding • mRNA 3'-UTR AU-rich region binding Cellular component • cytoplasm • perinuclear region of cytoplasm • cell nucleus Biological process • mRNA destabilization • mRNA localization resulting in posttranscriptional regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	399664	237400
Ensembl	ENSG00000181588	ENSMUSG00000048696
UniProt	Q86XN8	Q3UE17
RefSeq (mRNA)	NM_001174118 NM_203304	NM_198615
RefSeq (protein)	NP_001167589 NP_976049	NP_941017
Location (UCSC)	Chr 19: 1.55 – 1.57 Mb	Chr 10: 80.38 – 80.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[6]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000181588 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048696 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: mex-3 homolog D (C. elegans)".
6. Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.