MFAP2

Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene.[5][6]

MFAP2
Identifiers
Aliases	MFAP2, MAGP, MAGP-1, MAGP1, microfibrillar associated protein 2, microfibril associated protein 2
External IDs	OMIM: 156790 MGI: 99559 HomoloGene: 1801 GeneCards: MFAP2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 16,974,502 bp[1] End 16,980,632 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,010,418 bp[2] End 141,015,984 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • extracellular matrix structural constituent Cellular component • microfibril • extracellular region • collagen-containing extracellular matrix Biological process • embryonic eye morphogenesis • post-embryonic eye morphogenesis • extracellular matrix organization • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4237	17150
Ensembl	ENSG00000117122	ENSMUSG00000060572
UniProt	P55001	P55002 Q99PM0
RefSeq (mRNA)	NM_001135247 NM_001135248 NM_002403 NM_017459	NM_001161799 NM_008546 NM_001369292
RefSeq (protein)	NP_001128719 NP_001128720 NP_002394 NP_059453	NP_001155271 NP_032572 NP_001356221
Location (UCSC)	Chr 1: 16.97 – 16.98 Mb	Chr 4: 141.01 – 141.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same eight coding exons, and therefore, encode the same protein.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117122 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060572 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Faraco J, Bashir M, Rosenbloom J, Francke U (Jun 1995). "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170". Genomics. 25 (3): 630–7. doi:10.1016/0888-7543(95)80004-6. PMID 7759096.
6. "Entrez Gene: MFAP2 microfibrillar-associated protein 2".

Further reading

• Gibson MA, Hughes JL, Fanning JC, Cleary EG (1986). "The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein". J. Biol. Chem. 261 (24): 11429–36. doi:10.1016/S0021-9258(18)67403-4. PMID 3015971.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP (1996). "Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly". Biochem. J. 318 (1): 149–55. doi:10.1042/bj3180149. PMC 1217601. PMID 8761465.
• Finnis ML, Gibson MA (1997). "Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen". J. Biol. Chem. 272 (36): 22817–23. doi:10.1074/jbc.272.36.22817. PMID 9278443.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Fujimoto N, Tajima S, Ishibashi A (2000). "Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes". Arch. Dermatol. Res. 292 (1): 21–6. doi:10.1007/PL00007456. PMID 10664011. S2CID 36505268.
• Trask BC, Broekelmann T, Ritty TM, et al. (2001). "Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1)". Biochemistry. 40 (14): 4372–80. CiteSeerX 10.1.1.721.7743. doi:10.1021/bi002738z. PMID 11284693.
• Jensen SA, Reinhardt DP, Gibson MA, Weiss AS (2001). "Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1". J. Biol. Chem. 276 (43): 39661–6. doi:10.1074/jbc.M104533200. PMID 11481325.
• Reinboth B, Hanssen E, Cleary EG, Gibson MA (2002). "Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1". J. Biol. Chem. 277 (6): 3950–7. doi:10.1074/jbc.M109540200. PMID 11723132.
• Segade F, Trask BC, Broekelmann TJ, et al. (2002). "Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms". J. Biol. Chem. 277 (13): 11050–7. doi:10.1074/jbc.M110347200. PMID 11796718.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Werneck CC, Trask BC, Broekelmann TJ, et al. (2004). "Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2". J. Biol. Chem. 279 (22): 23045–51. doi:10.1074/jbc.M402656200. PMID 15044481.
• Clarke AW, Weiss AS (2004). "Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations". Eur. J. Biochem. 271 (14): 3085–90. doi:10.1111/j.1432-1033.2004.04246.x. PMID 15233806.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Miyamoto A, Lau R, Hein PW, et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation". J. Biol. Chem. 281 (15): 10089–97. doi:10.1074/jbc.M600298200. PMID 16492672.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.