MICAL2

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.[5][6]

MICAL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9K
Identifiers
Aliases	MICAL2, MICAL-2, MICAL2PV1, MICAL2PV2, microtubule associated monooxygenase, calponin and LIM domain containing 2
External IDs	OMIM: 608881 MGI: 2444947 HomoloGene: 8760 GeneCards: MICAL2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.3 Start 12,094,008 bp[1] End 12,359,144 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 112,225,856 bp[2] End 112,413,106 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • FAD binding • metal ion binding • monooxygenase activity • oxidoreductase activity • NADPH:sulfur oxidoreductase activity • NAD(P)H oxidase activity Cellular component • cell nucleus Biological process • heart looping • actin filament depolymerization • heart development • positive regulation of transcription via serum response element binding • cytoskeleton organization • sulfur oxidation • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9645	320878
Ensembl	ENSG00000133816	ENSMUSG00000038244
UniProt	O94851	Q8BML1
RefSeq (mRNA)	NM_001282663 NM_001282664 NM_001282665 NM_001282666 NM_001282667 NM_001282668 NM_001346292 NM_001346293 NM_001346294 NM_001346295 NM_001346296 NM_001346297 NM_001346298 NM_001346299 NM_014632	NM_001193305 NM_177282
RefSeq (protein)	NP_001269592 NP_001269593 NP_001269594 NP_001269595 NP_001269596 NP_001269597 NP_001333221 NP_001333222 NP_001333223 NP_001333224 NP_001333225 NP_001333226 NP_001333227 NP_001333228 NP_055447	NP_001180234 NP_796256
Location (UCSC)	Chr 11: 12.09 – 12.36 Mb	Chr 7: 112.23 – 112.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000133816 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038244 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
6. "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
• Ashida S, Furihata M, Katagiri T, et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression". Clin. Cancer Res. 12 (9): 2767–73. doi:10.1158/1078-0432.CCR-05-1995. PMID 16675569.