MIR222

MicroRNA 222 is a MicroRNA that in humans is encoded by the MIR222 gene, and is a known extracellular RNA (exRNA).[3]

MIR222
Identifiers
Aliases	MIR222, MIRN222, miRNA222, mir-222, microRNA 222
External IDs	OMIM: 300569 GeneCards: MIR222
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.3 Start 45,747,015 bp[1] End 45,747,124 bp[1]
Orthologs
Species	Human	Mouse
Entrez	407007	n/a
Ensembl	ENSG00000207725	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr X: 45.75 – 45.75 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

References

1. GRCh38: Ensembl release 89: ENSG00000207725 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: MicroRNA 222".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.