MOB1A

MOB kinase activator 1A is an enzyme that in humans is encoded by the MOB1A gene.[5][6]

MOB1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J1V, 4JIZ, 5BRK, 5BRM
Identifiers
Aliases	MOB1A, C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B, MOB kinase activator 1A
External IDs	OMIM: 609281 MGI: 2442631 HomoloGene: 10076 GeneCards: MOB1A
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,152,528 bp[1] End 74,178,898 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,326,016 bp[2] End 83,343,776 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding Cellular component • extracellular exosome • cell nucleus • nucleolus • cytosol Biological process • Hippo signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55233	232157
Ensembl	ENSG00000114978	ENSMUSG00000043131
UniProt	Q9H8S9	Q921Y0
RefSeq (mRNA)	NM_018221 NM_001317110 NM_001317111 NM_001317112	NM_145571
RefSeq (protein)	NP_001304039 NP_001304040 NP_001304041 NP_060691	NP_663546
Location (UCSC)	Chr 2: 74.15 – 74.18 Mb	Chr 6: 83.33 – 83.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000114978 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043131 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
6. "Entrez Gene: MOB kinase activator 1A".

Further reading

• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC (Sep 2003). "Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure. 11 (9): 1163–70. doi:10.1016/S0969-2126(03)00182-5. PMID 12962634.
• Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (Aug 2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". The Journal of Biological Chemistry. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
• Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y (Mar 2005). "Control of cell proliferation and apoptosis by mob as tumor suppressor, mats". Cell. 120 (5): 675–85. doi:10.1016/j.cell.2004.12.036. PMID 15766530. S2CID 13785447.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M (Aug 2007). "Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer". International Journal of Oncology. 31 (2): 333–8. doi:10.3892/ijo.31.2.333. PMID 17611689.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human MOB kinase activator 1A