MRPS2

Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. [5]

MRPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36
External IDs	OMIM: 611971 MGI: 2153089 HomoloGene: 99837 GeneCards: MRPS2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 135,499,984 bp[1] End 135,504,673 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,468,066 bp[2] End 28,471,178 bp[2]
Gene ontology Molecular function • structural constituent of ribosome Cellular component • small ribosomal subunit • ribosome • intracellular • mitochondrion • mitochondrial inner membrane • mitochondrial small ribosomal subunit Biological process • protein biosynthesis • mitochondrial translation • mitochondrial translational elongation • mitochondrial translational termination • mitochondrial ribosome assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51116	118451
Ensembl	ENSG00000122140	ENSMUSG00000035772
UniProt	Q9Y399	Q924T2
RefSeq (mRNA)	NM_016034 NM_001371401	NM_001166031 NM_080452
RefSeq (protein)	NP_057118 NP_001358330	NP_001159503 NP_536700
Location (UCSC)	Chr 9: 135.5 – 135.5 Mb	Chr 2: 28.47 – 28.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

See also

• Mitochondrial ribosome

References

1. GRCh38: Ensembl release 89: ENSG00000122140 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035772 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.