MTIF2

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[5][6][7]

MTIF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRV
Identifiers
Aliases	MTIF2, mitochondrial translational initiation factor 2
External IDs	OMIM: 603766 MGI: 1924034 HomoloGene: 1840 GeneCards: MTIF2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.1 Start 55,236,595 bp[1] End 55,269,347 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A3.3 Start 29,526,408 bp[2] End 29,545,279 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • translation factor activity, RNA binding • translation initiation factor activity • ribosomal small subunit binding • RNA binding • GTPase activity Cellular component • intracellular • mitochondrion • nucleoplasm Biological process • translational initiation • ribosome disassembly • protein biosynthesis • regulation of translational initiation • mitochondrial translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4528	76784
Ensembl	ENSG00000085760	ENSMUSG00000020459
UniProt	P46199 Q6P1N2	Q91YJ5
RefSeq (mRNA)	NM_001005369 NM_002453 NM_001321001 NM_001321002 NM_001321003 NM_001321004 NM_001321005	NM_001282118 NM_001282119 NM_001282120 NM_133767
RefSeq (protein)	NP_001005369 NP_001307930 NP_001307931 NP_001307932 NP_001307933 NP_001307934 NP_002444 NP_001005369.1 NP_002444.2	NP_001269047 NP_001269048 NP_001269049 NP_598528
Location (UCSC)	Chr 2: 55.24 – 55.27 Mb	Chr 11: 29.53 – 29.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000085760 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020459 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. S2CID 23290955.
6. Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
7. "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene". Biochim. Biophys. Acta. 1628 (3): 195–205. doi:10.1016/s0167-4781(03)00144-1. PMID 12932832.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Miura E, Kato Y, Matsushima R, et al. (2007). "The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants". Plant Cell. 19 (4): 1313–28. doi:10.1105/tpc.106.049270. PMC 1913758. PMID 17416734.