MYO6

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).

MYO6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N11, 2N13, 2N0Z, 2N10, 2N12
Identifiers
Aliases	MYO6, DFNA22, DFNB37, myosin VI, Myo6-008, Myo6-007
External IDs	OMIM: 600970 MGI: 104785 HomoloGene: 56417 GeneCards: MYO6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 75,749,192 bp[1] End 75,919,537 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 43.98 cM Start 80,165,031 bp[2] End 80,311,729 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cellular motor activity • actin filament binding • ATP binding • calmodulin binding • GO:0001948 protein binding • minus-end directed microfilament motor activity • ADP binding • actin binding • nucleotide binding • cadherin binding • identical protein binding Cellular component • myosin complex • cell nucleus • intracellular membrane-bounded organelle • cell projection • ruffle membrane • DNA-directed RNA polymerase II, holoenzyme • nucleoplasm • lysosomal membrane • perinuclear region of cytoplasm • clathrin-coated endocytic vesicle • apical part of cell • clathrin-coated vesicle membrane • ruffle • cytosol • extracellular exosome • membrane • clathrin-coated pit • filamentous actin • cell membrane • not the membrane • cytoplasm • cell cortex • microvilli • Golgi apparatus • unconventional myosin complex • endocytic vesicle • cytoplasmic vesicle • actin filament • macromolecular complex • clathrin-coated vesicle • filopodium Biological process • intracellular protein transport • actin filament-based movement • regulation of secretion • sensory perception of sound • positive regulation of transcription from RNA polymerase II promoter • protein transport • endocytosis • DNA damage response, signal transduction by p53 class mediator • response to drug • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4646	17920
Ensembl	ENSG00000196586	ENSMUSG00000033577
UniProt	Q9UM54	Q64331
RefSeq (mRNA)	NM_001300899 NM_004999 NM_001368136 NM_001368137 NM_001368138 NM_001368139 NM_001368140 NM_001368865 NM_001368866	NM_001039546 NM_008662
RefSeq (protein)	NP_001287828 NP_004990 NP_001355065 NP_001355066 NP_001355067 NP_001355068 NP_001355069 NP_001355794 NP_001355795	n/a
Location (UCSC)	Chr 6: 75.75 – 75.92 Mb	Chr 9: 80.17 – 80.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM][5]

Interactions

MYO6 has been shown to interact with GIPC1,[6][7] DAB2.,[8][9] ubiquitin,[10] and clathrin[11]

References

1. GRCh38: Ensembl release 89: ENSG00000196586 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033577 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MYO6 myosin VI".
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
7. Sennacherib L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.
8. Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
9. Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
10. He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ (2016). "Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains". Cell Reports. 14 (11): 2683–94. doi:10.1016/j.celrep.2016.01.079. PMC 4805485. PMID 26971995.
11. Biancospino M, Buel GR, Niño CA, Maspero E, di Perrotolo RS, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S (2019). "Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension". Nature Communications. 10 (1): 4974. Bibcode:2019NatCo..10.4974B. doi:10.1038/s41467-019-12855-6. PMC 6823378. PMID 31672988.

Further reading

• Buss F, Luzio JP, Kendrick-Jones J (Nov 2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Letters. 508 (3): 295–9. doi:10.1016/S0014-5793(01)03065-4. PMID 11728438. S2CID 44995651.
• Hasson T (Sep 2003). "Myosin VI: two distinct roles in endocytosis". Journal of Cell Science. 116 (Pt 17): 3453–61. doi:10.1242/jcs.00669. PMID 12893809.
• Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (Dec 1995). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nature Genetics. 11 (4): 369–75. doi:10.1038/ng1295-369. PMID 7493015. S2CID 29467878.
• Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA (Aug 1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Human Molecular Genetics. 6 (8): 1225–31. doi:10.1093/hmg/6.8.1225. PMID 9259267.
• Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". The Journal of Cell Biology. 143 (6): 1535–45. doi:10.1083/jcb.143.6.1535. PMC 2132970. PMID 9852149.
• Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (Sep 1999). "Myosin VI is an actin-based motor that moves backwards". Nature. 401 (6752): 505–8. Bibcode:1999Natur.401..505W. doi:10.1038/46835. PMID 10519557. S2CID 1420305.
• Buss F, Arden SD, Lindsay M, Luzio JP, Kendrick-Jones J (Jul 2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". The EMBO Journal. 20 (14): 3676–84. doi:10.1093/emboj/20.14.3676. PMC 125554. PMID 11447109.
• Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P (Sep 2001). "MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss". American Journal of Human Genetics. 69 (3): 635–40. doi:10.1086/323156. PMC 1235492. PMID 11468689.
• Yoshimura M, Homma K, Saito J, Inoue A, Ikebe R, Ikebe M (Oct 2001). "Dual regulation of mammalian myosin VI motor function". The Journal of Biological Chemistry. 276 (43): 39600–7. doi:10.1074/jbc.M105080200. PMID 11517222.
• Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL (Nov 2001). "Myosin VI is a processive motor with a large step size". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13655–9. Bibcode:2001PNAS...9813655R. doi:10.1073/pnas.191512398. PMC 61096. PMID 11707568.
• Inoue A, Sato O, Homma K, Ikebe M (Mar 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochemical and Biophysical Research Communications. 292 (2): 300–7. doi:10.1006/bbrc.2002.6636. PMID 11906161.
• Morris SM, Arden SD, Roberts RC, Kendrick-Jones J, Cooper JA, Luzio JP, Buss F (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic. 3 (5): 331–41. doi:10.1034/j.1600-0854.2002.30503.x. PMID 11967127. S2CID 25079713.
• Wu H, Nash JE, Zamorano P, Garner CC (Aug 2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". The Journal of Biological Chemistry. 277 (34): 30928–34. doi:10.1074/jbc.M203735200. PMID 12050163.
• Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER (May 2003). "Mutations of MYO6 are associated with recessive deafness, DFNB37". American Journal of Human Genetics. 72 (5): 1315–22. doi:10.1086/375122. PMC 1180285. PMID 12687499.
• Aschenbrenner L, Lee T, Hasson T (Jul 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Molecular Biology of the Cell. 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9UM54 (Unconventional myosin-VI) at the PDBe-KB.