MafB toxins

MafB toxins are exotoxins secreted by pathogenic Neisseria species (including meningococcus and gonococcus).

MafB toxins belong to the category of polymorphic toxins. The N-terminal region of MafB proteins harbors a domain of unknown function named DUF1020 while the C-terminal region is variable and harbors a toxic domain. MafB toxins are involved in interbacterial competition.[1][2]

References

Jamet, Anne; Jousset, Agnès B.; Euphrasie, Daniel; Mukorako, Paulette; Boucharlat, Alix; Ducousso, Alexia; Charbit, Alain; Nassif, Xavier (2015-01-01). "A new family of secreted toxins in pathogenic Neisseria species". PLOS Pathogens. 11 (1): e1004592. doi:10.1371/journal.ppat.1004592. ISSN 1553-7374. PMC 4287609. PMID 25569427.
Arenas, Jesús; de Maat, Vincent; Catón, Laura; Krekorian, Massis; Herrero, Juan Cruz; Ferrara, Flavio; Tommassen, Jan (2015-08-05). "Fratricide activity of MafB protein of N. meningitidis strain B16B6". BMC Microbiology. 15: 156. doi:10.1186/s12866-015-0493-6. ISSN 1471-2180. PMC 4524018. PMID 26242409.

External links

http://pfam.xfam.org/family/PF06255

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[1] Jamet, Anne; Jousset, Agnès B.; Euphrasie, Daniel; Mukorako, Paulette; Boucharlat, Alix; Ducousso, Alexia; Charbit, Alain; Nassif, Xavier (2015-01-01). "A new family of secreted toxins in pathogenic Neisseria species". PLOS Pathogens. 11 (1): e1004592. doi:10.1371/journal.ppat.1004592. ISSN 1553-7374. PMC 4287609. PMID 25569427.

[2] Arenas, Jesús; de Maat, Vincent; Catón, Laura; Krekorian, Massis; Herrero, Juan Cruz; Ferrara, Flavio; Tommassen, Jan (2015-08-05). "Fratricide activity of MafB protein of N. meningitidis strain B16B6". BMC Microbiology. 15: 156. doi:10.1186/s12866-015-0493-6. ISSN 1471-2180. PMC 4524018. PMID 26242409.