Magnus von Knebel Doeberitz

Magnus von Knebel Doeberitz is a molecular oncologist and virologist. He is a Professor of Molecular Oncology and Medical Director of Department of Applied Tumor Biology at the Institute of Pathology at the University Hospital of Heidelberg. He also heads a Clinical Cooperation at the German Cancer Research Center.[1]

Magnus von Knebel Doeberitz
OccupationPhysician and Professor of Molecular Oncology
AwardsErnst von Leyden Award for Cancer
Christoph-Wilhelm Hufeland Award for Cancer
Felix Burda Award
Academic background
EducationM.D.
Alma materUniversity of Freiburg
University of Kiel
Academic work
InstitutionsHeidelberg University

von Knebel Doeberitz has published over 300 research papers about viral and molecular carcinogenesis, early detection and prevention of cancer, novel prevention and therapeutic concepts and tumor immunology.[2]

von Knebel Doeberitz received the Ernst von Leyden award in 1998, the Christoph-Wilhelm Hufeland award in 2000, the Distinguished Service Award of Cervical Cancer in 2006 and the Felix Burda award in 2015.[3]

Education

von Knebel Doeberitz received his early academic education from the medical schools at Ghent in Belgium and then moved to Germany to study in medical schools of Hamburg, Freiburg and Kiel.[1] From 1985 till 1994, he completed his post-doctoral studies at the German Cancer Research Center in the laboratory Harald zur Hausen. During this tenure, he received his Habilitation degree and teaching license for Medical Microbiology and Molecular Oncology.[3]

Career

After his post-doctoral studies, von Knebel Doeberitz joined the University of Heidelberg in 1995 as a Professor of Molecular Oncology and Head of the Division of Molecular Diagnostics and Therapy at the Department of Surgery. In 2001, he was appointed as Medical Director of the Department of Applied Tumor Biology at the Institute of Pathology of the University Hospital Heidelberg.[1]

von Knebel Doeberitz served as a Scientific Advisor at Roche Diagnostics and Merck KG during the 1990s. In 1997, he co-founded LION bioscience Inc. and in 1999 he co-founded Molecular Tools in Medicine (MTM) Laboratories Inc. Since 2019 he has served as a member of the executive board of the Bioregion Rhein Neckar (BioRN).[4]

Research

von Knebel Doeberitz's major scientific interests relate to mechanisms of human carcinogenesis by papillomaviruses and DNA mismatch repair deficiency, the identification of novel diagnostic markers and potential therapeutic targets as well as their clinical validation and translation into routine medical care.[2]

Since the late 1980s, von Knebel Doeberitz has investigated the role of human papilloma virus (HPV) encoded transcripts in cervical cancer cells and confirmed the oncogenic role of the viral E6 and E7 proteins in HPV associated human carcinoma cells.[5]

In 1997 von Knebel Doeberitz discovered, that a cellular protein referred to as p16INK4a, is uniformly overexpressed in HPV-transformed cells and could be used as diagnostic tool to improve the early detection of cervical and other papillomavirus associated cancers. This work led to the development of the CINtec® product series at mtm-laboratories AG, a spin off company of the German Cancer Research Center co-founded by von Knebel Doeberitz and later acquired by Roche.[6][7]

DNA mismatch repair deficient cancers and Lynch syndrome

von Knebel Doeberitz and his research team pioneered the role of insertion and deletion mutations (InDels) in cancers that arise via the loss of DNA-mismatch repair functions that are also referred to as microsatellite instable cancers (MSI+). He was the first to show that patients develop specific immune responses to altered proteins encoded by the genes affected by these InDels and demonstrated that MSI cancers in particular patients affected by the Lynch syndrome predominantly develop via immune evasion mechanisms. Based on these findings von Knebel Doeberitz and his team develops vaccination strategies against hereditary cancer syndromes like Lynch.[8]

Awards/Honors
  • 1998 - Ernst von Leyden Award for Cancer - Early Detection and Prevention
  • 2000 - Christoph-Wilhelm Hufeland Award for Cancer - Early Detection and Prevention
  • 2006 - Distinguished Service Award of Cervical Cancer, Eurogin Congress
  • 2015 - Felix Burda Award[3]

Bibliography

Books
  • Atlas of Histopathology of the Cervix Uteri (1991) ISBN 978-3540522959
  • Color Atlas of Histopathology of the Cervix Uteri 2nd ed. (2006) ISBN 978-3642064333

Selected articles
  • Klaes, R., Woerner, S.M., Ridder, R., Wentzensen, N., Duerst, M., Schneider, A., Lotz, B., Melsheimer, P. and von Knebel Doeberitz, M., 1999. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer research, 59(24), pp. 6132–6136.
  • Klaes, R., Friedrich, T., Spitkovsky, D., Ridder, R., Rudy, W., Petry, U., Dallenbach‐Hellweg, G., Schmidt, D. and von Knebel Doeberitz, M., 2001. Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. International journal of cancer, 92(2), pp. 276–284.
  • Klaes, R., Benner, A., Friedrich, T., Ridder, R., Herrington, S., Jenkins, D., Kurman, R.J., Schmidt, D., Stoler, M. and von Knebel Doeberitz, M., 2002. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. The American journal of surgical pathology, 26(11), pp. 1389–1399.
  • Wentzensen, N., Vinokurova, S. and von Knebel Doeberitz, M., 2004. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer research, 64(11), pp. 3878–3884.
  • Zeller, G., Tap, J., Voigt, A.Y., Sunagawa, S., Kultima, J.R., Costea, P.I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N. and Hercog, R., 2014. Potential of fecal microbiota for early‐stage detection of colorectal cancer. Molecular systems biology, 10(11), p. 766.
  • Bergeron C, Ronco G, Reuschenbach M, Wentzensen N, Arbyn M, Stoler M, von Knebel Doeberitz M. 2015. The clinical impact of using p16(INK4a) immunochemistry in cervical histopathology and cytology: an update of recent developments. Int J Cancer. 136(12). pp. 2741–51.
  • Kloor M, von Knebel Doeberitz M. 2016. The Immune Biology of Microsatellite-Unstable Cancer. Trends Cancer. 2(3), pp. 121–133.

References
  1. "Universitätsklinikum Heidelberg: Overview". www.klinikum.uni-heidelberg.de.
  2. "Magnus von Knebel Doeberitz". scholar.google.de.
  3. "Felix Burda Award an Magnus von Knebel Doeberitz und Matthias Kloor". Felix Burda Award an Magnus von Knebel Doeberitz und Matthias Kloor.
  4. magazin, manager. "Sieger Start-up: Lion - manager magazin - manager magazin". www.manager-magazin.de.
  5. von Knebel Doeberitz, M.; Gissmann, L. (December 17, 1987). Neth, Rolf; Gallo, Robert C.; Greaves, Melvyn F.; Kabisch, Hartmut (eds.). "Analysis of the Biological Role of Human Papilloma Virus (HPV)-Encoded Transcripts in Cervical Carcinoma Cells by Antisense RNA". Springer. pp. 377–379. doi:10.1007/978-3-642-72624-8_80 – via Springer Link.
  6. "p16INK4a Immunohistochemistry Improves Interobserver... : The American Journal of Surgical Pathology".
  7. "Universitätsklinikum Heidelberg: Biomarkers and prevention". www.klinikum.uni-heidelberg.de.
  8. Ozcan, Mine; Janikovits, Jonas; Doeberitz, Magnus von Knebel; Kloor, Matthias (July 3, 2018). "Complex pattern of immune evasion in MSI colorectal cancer". OncoImmunology. 7 (7): e1445453. doi:10.1080/2162402X.2018.1445453. PMC 5993484. PMID 29900056 – via Taylor and Francis+NEJM.
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