Mehdi Mollapour

Mehdi Mollapour (born June 14, 1973) is a British-American Biochemist and Cancer Biologist. He is a Professor, Vice Chair for Translational Research and Director of Renal Cancer Biology Program for the Department of Urology, and Adjunct Professor at the Department of Biochemistry and Molecular Biology at SUNY Upstate Medical University.[1][2]

Mehdi Mollapour
Born1973
Alma materLondon School of Hygiene & Tropical Medicine, University College London
Known forRenal cancer research, Hsp90
Scientific career
FieldsUrology, Biochemistry
InstitutionsSUNY Upstate Medical University, National Cancer Institute, University of Sheffield

Education

Mollapour holds a BSc (Hons) in Microbiology and Biochemistry from the University of East London, MSc in Applied Molecular Biology of Infectious Diseases and Diploma in Tropical Medicine & Infectious Diseases from the London School of Hygiene & Tropical Medicine. In 2001 he received his PhD in Biochemistry from the University College London.[1]

Academic career

Mollapour completed his postdoctoral research at the University of Sheffield and in 2006 he received the Federation of European Societies (FEBS) fellowship.[1]

He joined the laboratory of Dr Len Neckers in Urological Oncology Branch, (Chief Dr. W. Marston Linehan), at the National Cancer Institute as a research fellow in 2007.[2]

In 2013 he joined the Department of Urology at the Upstate Medical University as an Assistant Professor. He became the Director of the Kidney Cancer Program within the same department in 2015.[1]

In 2018 he became the Professor of Urology and Adjunct Professor of Biochemistry and Molecular Biology at SUNY Upstate Medical University. He was also named the Vice Chair for Translational Research for the Department of Urology in the same year.[2]

Research

Mollapour is widely recognized for his research on post-translation regulation of the molecular chaperone Heat shock protein-90 (Hsp90) and co-chaperones in cancer. His work demonstrated how reversible biochemical reactions can become directional and ordered, and in general, how a house-keeping machine (Hsp90) can be modulated through signaling inputs. Mollapour’s finding on post-translational modifications of the Hsp90 chaperone machinery has also explained the reasons for tumors sensitivity and selectivity towards the Hsp90 inhibitors. [3][4]

Mollapour’s laboratory has discovered the tumor suppressor TSC1 and FNIPs function as the new co-chaperones of Hsp90. These two proteins are involved in Tuberous Sclerosis Complex and Birt–Hogg–Dubé syndrome (BHD) syndromes respectively. His research has identified a cross-talk between these two co-chaperones and demonstrated interconnectivity and compensatory mechanisms between the BHD and TSC pathways.[4]

His research team has been supported by grants from the National Institute of General Medical Sciences and the National Cancer Institute[5] to design and examine novel therapeutic strategies for patients with kidney, bladder and breast cancer. Mollapour’s current h-index is 39.[6]

Recognition

Selected publications

Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. Cell reports. 2019;26(5):1344-56 e5. Epub 2019/01/31. doi: 10.1016/j.celrep.2019.01.018. PubMed PMID 30699359; PubMed Central PMCID: PMCPMC6370319.

Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M. Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity. Oncotarget. 2019;10(56):5824-34. doi: 10.18632/oncotarget.27217. PubMed PMID 31645902; PubMed Central PMCID: PMCPMC6791385.

Sager RA, Woodford MR, Mollapour M. The mTOR Independent Function of Tsc1 and FNIPs. Trends Biochem Sci. 2018;43(12):935-7. Epub 2018/10/27. doi: 10.1016/j.tibs.2018.09.018. PubMed PMID 30361061.

Sager RA, Woodford MR, Neckers L, Mollapour M. Detecting Posttranslational Modifications of Hsp90. Methods Mol Biol. 2018;1709:209-19. doi: 10.1007/978-1-4939-7477-1_16. PubMed PMID 29177662.

Sager RA, Woodford MR, Shapiro O, Mollapour M, Bratslavsky G. Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dube: chaperones in pathogenesis. Oncotarget. 2018;9(31):22220-9. doi: 10.18632/oncotarget.25164. PubMed PMID 29774133; PubMed Central PMCID: PMCPMC5955167.

Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. EMBO J. 2017. doi: 10.15252/embj.201796700. PubMed PMID 29127155.

Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M. P hosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. Cell reports. 2017;21(7):1883-95. doi: 10.1016/j.celrep.2017.10.074. PubMed PMID 29141220.

Bratslavsky G, Woodford MR, Daneshvar M, Mollapour M. Sixth BHD symposium and first international upstate kidney cancer symposium: latest scientific and clinical discoveries. Oncotarget. 2016. doi: 10.18632/oncotarget.7733. PubMed PMID 26933819.

Woodford MR, Dunn D, Miller JB, Jamal S, Neckers L, Mollapour M. Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors. Adv Cancer Res. 2016;129:31-50. doi: 10.1016/bs.acr.2015.09.002. PubMed PMID 26916000.

Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature communications. 2016;7:12037. doi: 10.1038/ncomms12037. PubMed PMID 27353360; PubMed Central PMCID: PMCPMC4931344.

Woodford MR, Dunn DM, Ciciarelli JG, Beebe K, Neckers L, Mollapour M. Targeting Hsp90 in Non-Cancerous Maladies. Curr Top Med Chem. 2016. PubMed PMID 27072697.

Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Cell reports. 2016d;14(4):872-84. doi: 10.1016/j.celrep.2015.12.084. PubMed PMID 26804907.

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells. Cell reports. 2015;12(6):1006-18. doi: 10.1016/j.celrep.2015.07.004. PubMed PMID 26235616.

Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors. Mol Cell. 2014;53(2):317-29. doi: 10.1016/j.molcel.2013.12.007. PubMed PMID 24462205.

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M. Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity. Future medicinal chemistry. 2013;5(9):1059-71. doi: 10.4155/fmc.13.88. PubMed PMID 23734688.

Personal life

Mollapour is married to Dimitra Bourboulia, PhD, Assistant Professor, Assistant Dean for Undergraduate and Graduate Medical Education Research, and Director for the Office of Research for Medical Students, at SUNY Upstate Medical University.[10][11]

References
  1. "Mehdi Mollapour, MD". Upstate Medical University. Retrieved 2019-12-29.
  2. "Faculty1000 Prime: Medhi Mollapour Biography". Faculty of 1,000, Ltd. Retrieved 2020-01-01.
  3. "Phosphotyrosine Confers Client Specificity to Hsp90". Molecular Cell. Retrieved 2020-01-01.
  4. "Regulatory Posttranslational Modifications in Hsp90 Can Be Compensated by Cochaperone Aha1". Molecular Cell. Retrieved 2020-01-01.
  5. "Fall Newsletter 2017". Upstate Medical University. Retrieved 2020-01-01.
  6. "Google Scholar: Mehdi Mollapour". Google Scholar. Retrieved 2020-01-01.
  7. "Cell Stress Society International Fellows". Cell Stress Society International.
  8. "Fall Newsletter 2017" (PDF). Society for Basic Urologic Research. Retrieved 2020-01-01.
  9. "The Ferruccio Ritossa Early Career Award". Cell Stress Society International. Retrieved 2020-01-01.
  10. "Upstate Leadership". Upstate Medical University. Retrieved 2020-01-02.
  11. "Bourboulia Lab". Dimitra Bourboulia. Retrieved 2020-01-02.
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