Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction
- methanol + 5-hydroxybenzimidazolylcobamide Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O
| methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.90 | ||||||||
| CAS number | 86611-98-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.
References
Further reading
- van der Meijden P, te Brömmelstroet BW, Poirot CM, van der Drift C, Vogels GD (November 1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". Journal of Bacteriology. 160 (2): 629–35. doi:10.1128/JB.160.2.629-635.1984. PMC 214781. PMID 6438059.