Methylenomycin B

Methylenomycin B is a cyclopentanone derived antibiotic produced by Streptomyces coelicolor A3(2) that is effective against both Gram-negative and Gram-positive bacteria.[1][2] Methylenomycins are naturally produced in two variants: A and B.

Methylenomycin B

Names
IUPAC name 2,3-Dimethyl-5-methylene-2-cyclopenten-1-one
Identifiers
CAS Number	52775-77-6
3D model (JSmol)	Interactive image
ChemSpider	2303992
PubChem CID	3040648
UNII	WLO3E84KAS
CompTox Dashboard (EPA)	DTXSID50200755
InChI InChI=1S/C8H10O/c1-5-4-6(2)8(9)7(5)3/h2,4H2,1,3H3 Key: YDXIEAHUYZKJOH-UHFFFAOYSA-N InChI=1/C8H10O/c1-5-4-6(2)8(9)7(5)3/h2,4H2,1,3H3 Key: YDXIEAHUYZKJOH-UHFFFAOYAN
SMILES O=C/1\C(=C)CC(=C\1C)\C
Properties
Chemical formula	C8H10O
Molar mass	122.167 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

See also

• Methylenomycin A

References

1. Brian P, Riggle PJ, Santos RA, Champness WC (June 1996). "Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system". J. Bacteriol. 178 (11): 3221–31. doi:10.1128/jb.178.11.3221-3231.1996. PMC 178074. PMID 8655502.
2. Hobbs G, Obanye AI, Petty J, et al. (March 1992). "An integrated approach to studying regulation of production of the antibiotic methylenomycin by Streptomyces coelicolor A3(2)". J. Bacteriol. 174 (5): 1487–94. doi:10.1128/jb.174.5.1487-1494.1992. PMC 206543. PMID 1537793.