Mir-744 microRNA precursor family

In molecular biology mir-744 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-744
Identifiers
Symbolmir-744
RfamRF00936
miRBase familyMIPF0000431
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

miR-744 and cancer in mice

miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst knockdown sees a resultant decreased level of mouse cyclin B through the Ccnb1 gene.[1] Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal instability and in vivo suppression are concurrent with a prolonged expression.

TGF-β1 repression

Multiple miR-744 binding sites have been identified in the proximal 3' untranslated region of transforming growth factor beta 1 (TGF-β1). Direct targeting of TGF-β1 by miR-744 has been identified, and transfection is seen to inhibit endogenous TGF-β1 synthesis by directing post-transcriptional regulation.[2]

EEF1A2 repression

miR-744 directly targets translation elongation factor and known protooncogene EEF1A2.[3] mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells.[4]

See also

References
  1. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, et al. (2012). "Upregulation of Cyclin B1 by miRNA and its implications in cancer". Nucleic Acids Res. 40 (4): 1695–707. doi:10.1093/nar/gkr934. PMC 3287204. PMID 22053081.
  2. Martin J, Jenkins RH, Bennagi R, Krupa A, Phillips AO, Bowen T, et al. (2011). "Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744". PLoS ONE. 6 (10): e25044. doi:10.1371/journal.pone.0025044. PMC 3186795. PMID 21991303.
  3. Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.
  4. Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.

Further reading


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