Miratul Muqit

Miratul Muqit FRSE[1] is a British neurologist and a Programme Lead at the MRC Protein Phosphorylation and Ubiquitylation Unit (MRCPPU) in the School of Life Sciences at the University of Dundee.[2] His research focuses on the study of the PINK1 gene, mutations in which are a major cause of Parkinson’s disease.[2][3]

Miratul Muqit
Born1973
Glasgow, Scotland
Alma materUniversity of Edinburgh, Harvard University, University College London
OccupationConsultant Neurologist, Professor
OrganizationUniversity of Dundee
Known forContributions to the study of PINK1 in Parkinson’s disease
Websitehttps://www.ppu.mrc.ac.uk/research/principal-investigator/miratul-muqit

Education and career

Muqit studied medicine at the University of Edinburgh and graduated with Honours in 1997.[4] During his studies he became interested in neurodegenerative diseases, and in 2000 he was awarded a Kennedy scholarship[5] at Harvard University which he completed within a year of study.[6] His interest in neurodegeneration led him to study for a PhD in University College London’s Institute of Neurology, awarded to him in 2007.[7][8][9]

He also received clinical training in medicine and neurology at the Hammersmith Hospital and the National Hospital for Neurology and Neurosurgery in London.[7][8]

He joined the MRC PPU at the University of Dundee in 2008 and has worked there since combining laboratory research and clinical work as a Consultant Neurologist specialising in Movement Disorders.[7][8][10] He was appointed Professor of Experimental Neurology in October 2018.[11]

Research

Muqit’s research focuses on the protein PINK1, study of which he began during his PhD in UCL. He is credited as a major contributor to the discovery of PINK1 mutations as a cause of Parkinson's disease, and he has been working on it ever since.[7][10][12]

PINK1 is a kinase which normally senses damaged mitochondria and targets them for destruction, and mutations which interrupt its function will induce Parkinson’s disease. Much of his research focuses on characterising PINK1 to understand its signalling pathway and the effects of it and its mutations on the cell, in order to help find treatments for Parkinson's Disease.[2][10][13]

His research team at the university of Dundee has already discovered substrates of PINK1 such as Parkin and Ubiquitin, which have helped to clarify the function of this kinase. They have also made an effort to understand the mechanisms of activation and regulation of PINK1.[3]

Impact

Muqit’s research on Parkinson's and other neurological diseases has been cited by the larger scientific community over 10000 times[14]

Muqit is a member of the scientific advisory board of Mitokinin Inc.[15] He was formerly on the scientific advisory board of Amgen Inc.

His work was also covered widely on media including TV news, Scotland Tonight, where he was asked for his professional take on the subject.[16]

Awards
  • Queen Square Prize in Neurology (2006)[17]
  • Wellcome Trust Senior Fellowship in Clinical Science (2013)[2][8]
  • Fellow of the Royal College of Physicians (2016)[19]
  • Graham Bull Prize in Clinical Science & Goulstonian Lecture of the Royal College of Physicians (RCP) (2018)[21]
  • Royal Society Francis Crick Medal and Lecture (2018)[22]
  • Brian Cox Prize in public engagement (2019)[23]
  • Fellow of the Royal Society of Edinburgh (2020)[1]

References
  1. "Professor Miratul Muqit FRSE". The Royal Society of Edinburgh. 2020-08-24. Retrieved 2020-08-27.
  2. MMuqit (2013-09-02). "Professor Miratul Muqit FRSE". School of Life Sciences. Retrieved 2020-08-27.
  3. "Miratul Muqit". ppu.mrc.ac.uk. Retrieved 2020-07-15.
  4. "Edinburgh University". HeraldScotland. Retrieved 2020-08-27.
  5. "Kennedy Memorial Trust". www.kennedytrust.org.uk. Retrieved 2020-08-27.
  6. "Harvard BBS PhD Program". hms.harvard.edu. Retrieved 2020-08-20.
  7. "Principal investigator". ppu.mrc.ac.uk. Retrieved 2020-08-27.
  8. "Miratul Muqit". Linked In. Retrieved 2020-07-15.
  9. "World Parkinson's Day 2020 – Q&A with Professor Miratul Muqit". The Royal Society Blog. 2020-04-11. Retrieved 2020-08-27.
  10. "Miratul Muqit, MD, PhD". The Michael J. Fox Foundation for Parkinson's Research | Parkinson's Disease. Retrieved 2020-08-27.
  11. amycameron (2018-10-23). "Professorships for Kim Dale and Miratul Muqit". School of Life Sciences. Retrieved 2020-08-27.
  12. "Scopus preview - Scopus - Author details (Muqit, Miratul M.K.)". www.scopus.com. Retrieved 2020-08-27.
  13. McWilliams, Thomas G; Muqit, Miratul MK (2017-04-22). "PINK1 and Parkin: emerging themes in mitochondrial homeostasis". Current Opinion in Cell Biology. 45: 83–91. doi:10.1016/j.ceb.2017.03.013. PMID 28437683.
  14. "Miratul Muqit - Google Scholar". scholar.google.co.uk. Retrieved 2020-08-27.
  15. "About Us". Mitokinin. Retrieved 2020-08-27.
  16. "Scotland tonight tweet". Twitter. Retrieved 2020-08-27.
  17. "Queen Square Alumnus Association Newsletter number 29" (PDF). 2007. Retrieved 2020-08-27.
  18. SHussain (2013-12-13). "Royal College of Physicians honour for Miratul Muqit". School of Life Sciences. Retrieved 2020-08-27.
  19. "Miratul Muqit elected Fellow of the Royal College of Physicians". ppu.mrc.ac.uk. Retrieved 2020-08-27.
  20. "Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 2020-08-27.
  21. Dundee, University of. "Dundee Clinician Scientist Receives Prestigious Medical Prize : News". University of Dundee. Retrieved 2020-08-27.
  22. "Francis Crick Medal and Lecture | Royal Society". royalsociety.org. Retrieved 2020-08-27.
  23. amycameron (2020-01-15). "Brian Cox Prize - Engaged Researcher". School of Life Sciences. Retrieved 2020-08-27.
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