Mitochondrial fission factor

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.[3] Its primary role is in controlling the division of mitochondria. It has also been shown to regulate peroxisome morphology.[4]

MFF
Identifiers
Aliases	MFF, C2orf33, GL004, mitochondrial fission factor, EMPF2
External IDs	OMIM: 614785 HomoloGene: 137341 GeneCards: MFF
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.3 Start 227,325,151 bp[1] End 227,357,836 bp[1]
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • synaptic vesicle • peroxisome • synapse • mitochondrial outer membrane • cell junction • integral component of mitochondrial membrane • cytoplasmic vesicle • mitochondrion Biological process • mitochondrial fusion • mitochondrial fragmentation involved in apoptotic process • positive regulation of mitochondrial fission • mitochondrial fission • regulation of mitochondrion organization • regulation of peroxisome organization • protein targeting to mitochondrion • peroxisome fission • positive regulation of release of cytochrome c from mitochondria • mitochondrion morphogenesis • protein homooligomerization • release of cytochrome c from mitochondria • positive regulation of protein targeting to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56947	n/a
Ensembl	ENSG00000168958	n/a
UniProt	Q9GZY8	n/a
RefSeq (mRNA)	NM_001277061 NM_001277062 NM_001277063 NM_001277064 NM_001277065 NM_001277066 NM_001277067 NM_001277068 NM_020194	n/a
RefSeq (protein)	NP_001263990 NP_001263991 NP_001263992 NP_001263993 NP_001263994 NP_001263995 NP_001263996 NP_001263997 NP_064579	n/a
Location (UCSC)	Chr 2: 227.33 – 227.36 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Role in mitochondrial fission

Mff is an outer mitochondrial membrane protein that binds to the GTPase Drp1; the Mff-Drp1 complex is what promotes mitochondrial fission. Knockdown of Mff causes the mitochondrial network to expand (by releasing the Drp1 foci from the outer mitochondrial membrane), while Mff overexpression causes it to become fragmented (by stimulating mitochondrial recruitment of Drp1).[5]

References

1. GRCh38: Ensembl release 89: ENSG00000168958 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: mitochondrial fission factor".
4. Gandre-Babbe S, van der Bliek AM (Jun 2008). "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell. 19 (6): 2402–12. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969.
5. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (Dec 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–58. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.

Further reading

• Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, Cengiz B, Gogebakan B, Cakmak EA, Demiryurek AT (Jun 2011). "Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma". Endocrine Pathology. 22 (2): 86–96. doi:10.1007/s12022-011-9157-8. PMID 21509594. S2CID 11869197.