Motile sperm domain containing 2

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene.[5] It is an endoplasmic reticulum–resident protein involved in membrane contact site formation.[6] Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

MOSPD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIC
Identifiers
Aliases	MOSPD2, Motile sperm domain containing 2
External IDs	MGI: 1924013 HomoloGene: 22125 GeneCards: MOSPD2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 14,873,421 bp[1] End 14,922,327 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 164,936,169 bp[2] End 164,980,375 bp[2]
Orthologs
Species	Human	Mouse
Entrez	158747	76763
Ensembl	ENSG00000130150	ENSMUSG00000061778
UniProt	Q8NHP6	Q9CWP6
RefSeq (mRNA)	NM_001177475 NM_152581 NM_001330241	NM_001290523 NM_001290524 NM_029730
RefSeq (protein)	NP_001170946 NP_001317170 NP_689794	NP_001277452 NP_001277453 NP_084006
Location (UCSC)	Chr X: 14.87 – 14.92 Mb	Chr X: 164.94 – 164.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130150 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061778 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Motile sperm domain containing 2".
6. Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F (June 2018). "Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites". EMBO Reports. 19 (7): e45453. doi:10.15252/embr.201745453. PMC 6030701. PMID 29858488.

Further reading

• Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E, Edwards TL (March 2013). "Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study". Human Genetics. 132 (3): 323–36. doi:10.1007/s00439-012-1246-3. PMC 3704217. PMID 23192594.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain-containing protein 2