Multi-Ethnic Study of Atherosclerosis

The Multi-Ethnic Study of Atherosclerosis (abbreviated MESA) is an ongoing medical study which aims to investigate the characteristics of subclinical atherosclerosis and other cardiovascular diseases, and to determine risk factors for its progression to the clinically overt form of these diseases.[1] Sponsored by the National Heart, Lung and Blood Institute, MESA was begun in July 2000, and it follows a population-based sample of 6,814 American men and women aged 45 to 84, recruited from six field centers.[2][3] The diverse sample consists of 38% White subjects, 28% African American, 22% Hispanic, and 12% Asian (primarily Chinese).[2][nb 1] Over 1,000 peer-reviewed papers have been published based on MESA and its 145 independent ancillary studies (as of September 2016).[4]

Timeline

Originally established in 1999,[5] MESA began recruiting subjects in July 2000 for a baseline examination, which was completed in September 2002. The patients were recruited from each of the study's six field centers, which were located in Baltimore, Maryland; Chicago, Illinois; Forsyth County, North Carolina; Los Angeles, California; New York, New York; and St. Paul, Minnesota.[6] The baseline exam measured the subjects' coronary calcification and ventricular mass, among other outcomes.[7] Three subsequent examinations, each of which lasted from 17 to 20 months, were subsequently conducted, and a fifth examination lasted from April 2010 to January 2012.[2]

Notes
  1. When the subjects were originally recruited, their ethnic composition was as follows: 38% White, 28% African-American, 23% Hispanic, and 11% Asian.[3]

References
  1. "About MESA". www.mesa-nhlbi.org. Retrieved 2018-05-24.
  2. "MESA Overview and Protocol". www.mesa-nhlbi.org. Retrieved 2018-05-24.
  3. Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacob DR, Kronmal R, Liu K, Nelson JC, O'Leary D, Saad MF, Shea S, Szklo M, Tracy RP (November 2002). "Multi-Ethnic Study of Atherosclerosis: objectives and design" (PDF). American Journal of Epidemiology. 156 (9): 871–81. doi:10.1093/aje/kwf113. PMID 12397006.
  4. Burke G, Lima J, Wong ND, Narula J (September 2016). "The Multiethnic Study of Atherosclerosis". Global Heart. 11 (3): 267–268. doi:10.1016/j.gheart.2016.09.001. PMID 27741973.
  5. "Multi-Ethnic Study of Atherosclerosis (MESA)". www.nhlbi.nih.gov. Retrieved 2018-05-24.
  6. Folsom AR, Kronmal RA, Detrano RC, O'Leary DH, Bild DE, Bluemke DA, Budoff MJ, Liu K, Shea S, Szklo M, Tracy RP, Watson KE, Burke GL (June 2008). "Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA)". Archives of Internal Medicine. 168 (12): 1333–9. doi:10.1001/archinte.168.12.1333. PMC 2555989. PMID 18574091.
  7. "The Multi-Ethnic Study of Atherosclerosis (MESA)Obesity Research - NHLBI, NIH". www.nhlbi.nih.gov. Retrieved 2018-05-24.
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