Myb proto-oncogene like 1

MYB proto-oncogene like 1 is a protein that in humans is encoded by the MYBL1 gene. [5]

MYBL1
Identifiers
Aliases	MYBL1, A-MYB, AMYB, MYB proto-oncogene like 1
External IDs	OMIM: 159405 MGI: 99925 HomoloGene: 32045 GeneCards: MYBL1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 66,562,175 bp[1] End 66,614,247 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A2|1 2.08 cM Start 9,667,415 bp[2] End 9,700,209 bp[2]
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • GO:0007067 mitotic cell cycle • male meiosis I • spermatogenesis • negative regulation of transposition • cell differentiation • piRNA biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4603	17864
Ensembl	ENSG00000185697	ENSMUSG00000025912
UniProt	P10243	P51960
RefSeq (mRNA)	NM_001080416 NM_001144755 NM_001294282	NM_001290397 NM_008651
RefSeq (protein)	NP_001073885 NP_001138227 NP_001281211	NP_001277326 NP_032677
Location (UCSC)	Chr 8: 66.56 – 66.61 Mb	Chr 1: 9.67 – 9.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185697 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025912 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MYB proto-oncogene like 1". Retrieved 2016-11-15.

Further reading

• Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL (2013). "Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1". Proc. Natl. Acad. Sci. U.S.A. 110 (20): 8188–93. doi:10.1073/pnas.1300252110. PMC 3657784. PMID 23633565.