NDUFAF8

NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene.[3] This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.[4]

NDUFAF8
Identifiers
Aliases	NDUFAF8, C17orf89, NADH:ubiquinone oxidoreductase complex assembly factor 8
External IDs	OMIM: 618461 MGI: 1913676 HomoloGene: 83602 GeneCards: NDUFAF8
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • mitochondrion Biological process • mitochondrial respiratory chain complex I assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284184	208501
Ensembl	ENSG00000224877	n/a
UniProt	A1L188	A2AMZ4
RefSeq (mRNA)	NM_001086521	NM_001110242
RefSeq (protein)	NP_001079990 NP_001340331 NP_001340332	NP_001103712
Location (UCSC)	n/a	n/a
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Structure

The NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs.[3] The gene produces a 7.756 kDa protein composed of 74 amino acids.[5][6]

Function

The protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.[4]

Interaction

NDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.[4]

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: NADH:ubiquinone oxidoreductase complex assembly factor 8". Retrieved 2018-07-27.
4. "NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene & protein". www.uniprot.org. Retrieved 2018-07-27.
5. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
6. "Uncharacterized protein C17orf89". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.