NOTUM (gene)

Notum, palmitoleoyl-protein carboxylesterase is a protein that in humans is encoded by the NOTUM gene. [5]

NOTUM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UYU, 4UYW, 4UYZ, 4UZ1, 4UZ5, 4UZ6, 4UZ7, 4UZ9, 4UZA, 4UZL, 4UZQ, 4WBH
Identifiers
Aliases	NOTUM, hpalmitoleoyl-protein carboxylesterase
External IDs	OMIM: 609847 MGI: 1924833 HomoloGene: 45335 GeneCards: NOTUM
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,952,507 bp[1] End 81,961,840 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,653,788 bp[2] End 120,661,175 bp[2]
Gene ontology Molecular function • palmitoleyl hydrolase activity • GO:0004091 carboxylic ester hydrolase activity • hydrolase activity • phospholipase C activity Cellular component • extracellular region • endoplasmic reticulum lumen Biological process • negative regulation of Wnt signaling pathway • protein depalmitoleylation • Wnt signaling pathway • negative regulation of canonical Wnt signaling pathway • post-translational modification • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147111	77583
Ensembl	ENSG00000185269	ENSMUSG00000042988
UniProt	Q6P988	Q8R116
RefSeq (mRNA)	NM_178493	NM_175263 NM_001382269 NM_001382270
RefSeq (protein)	NP_848588	NP_780472 NP_001369198 NP_001369199
Location (UCSC)	Chr 17: 81.95 – 81.96 Mb	Chr 11: 120.65 – 120.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185269 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042988 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Notum, palmitoleoyl-protein carboxylesterase". Retrieved 2018-06-15.

Further reading

• Torisu Y, Watanabe A, Nonaka A, Midorikawa Y, Makuuchi M, Shimamura T, Sugimura H, Niida A, Akiyama T, Iwanari H, Kodama T, Zeniya M, Aburatani H (June 2008). "Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF". Cancer Sci. 99 (6): 1139–46. doi:10.1111/j.1349-7006.2008.00814.x. PMID 18429952. S2CID 13526819.
• Kakugawa S, Langton PF, Zebisch M, Howell S, Chang TH, Liu Y, Feizi T, Bineva G, O'Reilly N, Snijders AP, Jones EY, Vincent JP (March 2015). "Notum deacylates Wnt proteins to suppress signalling activity". Nature. 519 (7542): 187–192. doi:10.1038/nature14259. PMC 4376489. PMID 25731175.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Palmitoleoyl-protein carboxylesterase NOTUM