NOVA1

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.[5][6]

NOVA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DT4, 2ANN, 2ANR
Identifiers
Aliases	NOVA1, Nova-1, NOVA alternative splicing regulator 1
External IDs	OMIM: 602157 MGI: 104297 HomoloGene: 21296 GeneCards: NOVA1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 26,443,093 bp[1] End 26,597,754 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 B3|12 21.46 cM Start 46,694,517 bp[2] End 46,818,929 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • mRNA binding • RNA binding • GO:0001948 protein binding Cellular component • nucleolus • intracellular membrane-bounded organelle • cell nucleus Biological process • mRNA splicing, via spliceosome • RNA processing • locomotory behavior • RNA splicing • regulation of RNA metabolic process • chemical synaptic transmission • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4857	664883
Ensembl	ENSG00000139910	ENSMUSG00000021047
UniProt	P51513	Q9JKN6
RefSeq (mRNA)	NM_002515 NM_006489 NM_006491	NM_021361 NM_001364634 NM_001364635 NM_001364636 NM_001364637 NM_001364638 NM_001364639
RefSeq (protein)	NP_002506 NP_006480 NP_006482 NP_001353319 NP_001353320 NP_001353321 NP_001353322 NP_001353323 NP_001353324 NP_001353325 NP_001353326 NP_001353327	NP_067336 NP_001351563 NP_001351564 NP_001351565 NP_001351566 NP_001351567 NP_001351568
Location (UCSC)	Chr 14: 26.44 – 26.6 Mb	Chr 12: 46.69 – 46.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000139910 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021047 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Buckanovich RJ, Yang YY, Darnell RB (Feb 1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies". J Neurosci. 16 (3): 1114–22. PMID 8558240.
6. "Entrez Gene: NOVA1 neuro-oncological ventral antigen 1".

Further reading

• Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system". Neuron. 11 (4): 657–72. doi:10.1016/0896-6273(93)90077-5. PMID 8398153.
• Buckanovich RJ, Darnell RB (1997). "The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo". Mol. Cell. Biol. 17 (6): 3194–201. PMC 232172. PMID 9154818.
• Lewis HA, Chen H, Edo C, et al. (1999). "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains". Structure. 7 (2): 191–203. doi:10.1016/S0969-2126(99)80025-2. PMID 10368286.
• Jensen KB, Dredge BK, Stefani G, et al. (2000). "Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability". Neuron. 25 (2): 359–71. doi:10.1016/S0896-6273(00)80900-9. PMID 10719891.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dredge BK, Darnell RB (2003). "Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer". Mol. Cell. Biol. 23 (13): 4687–700. doi:10.1128/MCB.23.13.4687-4700.2003. PMC 164843. PMID 12808107.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ule J, Ule A, Spencer J, et al. (2005). "Nova regulates brain-specific splicing to shape the synapse". Nat. Genet. 37 (8): 844–52. doi:10.1038/ng1610. PMID 16041372.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.