NSL1

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.[5]

NSL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NF9
Identifiers
Aliases	NSL1, C1orf48, MIS14, DC8, MIS12 kinetochore complex component, NSL1 component of MIS12 kinetochore complex
External IDs	OMIM: 609174 MGI: 2685830 HomoloGene: 22898 GeneCards: NSL1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 212,726,153 bp[1] End 212,791,782 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 191,063,012 bp[2] End 191,086,474 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • MIS12/MIND type complex • chromosome, centromeric region • cell nucleus • kinetochore • chromosome • nucleoplasm • nuclear speck • condensed chromosome kinetochore • cytosol Biological process • cell division • cell cycle • chromosome segregation • mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25936	381318
Ensembl	ENSG00000117697	ENSMUSG00000062510
UniProt	Q96IY1	Q8K305
RefSeq (mRNA)	NM_015471 NM_001042549 NM_001297736 NM_001297737 NM_001297739	NM_198654
RefSeq (protein)	NP_001036014 NP_001284665 NP_001284666 NP_001284668 NP_056286	n/a
Location (UCSC)	Chr 1: 212.73 – 212.79 Mb	Chr 1: 191.06 – 191.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

NSL1 has been shown to interact with MIS12[6] and DSN1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117697 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062510 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)".
6. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS". Biochim. Biophys. Acta. 1773 (9): 1398–406. doi:10.1016/j.bbamcr.2007.05.013. PMID 17604136.