NUPL2

Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene.[5][6][7]

NUP42
Identifiers
Aliases	NUP42, CG1, NLP-1, NLP_1, hCG1, nucleoporin like 2, NUPL2, nucleoporin 42
External IDs	MGI: 2387631 HomoloGene: 40573 GeneCards: NUP42
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 23,181,841 bp[1] End 23,201,011 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 24,164,963 bp[2] End 24,184,013 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nuclear export signal receptor activity • metal ion binding • GO:0001948 protein binding • RNA binding Cellular component • not the membrane • nuclear envelope • membrane • nuclear pore • nucleoplasm • cell nucleus • cytosol • host cell Biological process • mRNA transport • viral transcription • protein sumoylation • mitotic nuclear envelope disassembly • protein export from nucleus • regulation of cellular response to heat • protein transport • GO:0022415 viral process • GO:0046795 intracellular transport of virus • mRNA export from nucleus • tRNA export from nucleus • regulation of gene silencing by miRNA • regulation of glycolytic process • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11097	231042
Ensembl	ENSG00000136243	ENSMUSG00000048439
UniProt	O15504	Q8CIC2
RefSeq (mRNA)	NM_007342 NM_001370443 NM_001370444 NM_001370445 NM_001370446	NM_153092 NM_001346582
RefSeq (protein)	NP_031368 NP_001357372 NP_001357373 NP_001357374 NP_001357375	NP_001333511 NP_694732
Location (UCSC)	Chr 7: 23.18 – 23.2 Mb	Chr 5: 24.16 – 24.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048439 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem. 274 (24): 17309–17317. doi:10.1074/jbc.274.24.17309. PMID 10358091.
6. Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet. 5 (6): 397–405. PMID 9450185.
7. "Entrez Gene: NUPL2 nucleoporin like 2".

Further reading

• Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. doi:10.1128/JVI.72.7.6004-6013.1998. PMC 110405. PMID 9621063.
• Katahira J, Strässer K, Podtelejnikov A, et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–2609. doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171.
• Strahm Y, Fahrenkrog B, Zenklusen D, et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p". EMBO J. 18 (20): 5761–5777. doi:10.1093/emboj/18.20.5761. PMC 1171643. PMID 10610322.
• de Noronha CM, Sherman MP, Lin HW, et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr". Science. 294 (5544): 1105–1108. doi:10.1126/science.1063957. PMID 11691994. S2CID 29771914.
• Le Rouzic E, Mousnier A, Rustum C, et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–45098. doi:10.1074/jbc.M207439200. PMID 12228227.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sasaki M, Takeda E, Takano K, et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products". Genomics. 85 (5): 641–653. doi:10.1016/j.ygeno.2005.01.003. PMID 15820316.
• Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA". Mol. Biol. Cell. 16 (9): 4304–4315. doi:10.1091/mbc.E04-11-0998. PMC 1196339. PMID 16000379.
• Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion. 4 (2–3): 223–233. doi:10.1016/j.mito.2004.06.012. PMID 16120388.