NXPH1

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.[5][6]

NXPH1
Identifiers
Aliases	NXPH1, NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639 MGI: 107492 HomoloGene: 8284 GeneCards: NXPH1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.3 Start 8,433,609 bp[1] End 8,752,961 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 8,948,431 bp[2] End 9,249,032 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30010	18231
Ensembl	ENSG00000122584	ENSMUSG00000046178
UniProt	P58417	Q61200
RefSeq (mRNA)	NM_152745	NM_008751
RefSeq (protein)	NP_689958	NP_032777
Location (UCSC)	Chr 7: 8.43 – 8.75 Mb	Chr 6: 8.95 – 9.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.
6. "Entrez Gene: NXPH1 neurexophilin 1".

Further reading

• Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
• Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi:10.1523/JNEUROSCI.16-14-04360.1996. PMC 6578849. PMID 8699246.
• Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi:10.1074/jbc.273.52.34716. PMID 9856994.
• Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.